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Unusual CD4+CD28- T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders
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Type
Academic journal
Author
Ga Hye Lee (Seoul National University College of Medicine) Won-Woo Lee (Seoul National University College of Medicine)
Journal
The Korean Association of Immunologists Immune Network Vol.16 No.6 KCI Accredited Journals SCIE
Published
2016.12
Pages
322 - 329 (8page)

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Unusual CD4+CD28- T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders
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Abstract· Keywords

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CD28 is a primary co-stimulatory receptor that is essential for successful T cell activation, proliferation, and survival. While ubiquitously expressed on naive T cells, the level of CD28 expression on memory T cells is largely dependent on the T-cell differentiation stage in humans. Expansion of circulating T cells lacking CD28 was originally considered a hallmark of age-associated immunological changes in humans, with a progressive loss of CD28 following replicative senescence with advancing age. However, an increasing body of evidence has revealed that there is a significant age-inappropriate expansion of CD4<SUP>+</SUP>CD28<SUP>–</SUP> T cells in patients with a variety of chronic inflammatory diseases, suggesting that these cells play a role in their pathogenesis. In fact, expanded CD4+CD28– T cells can produce large amounts of proinflammatory cytokines such as IFN-γ and TNF-α and also have cytotoxic potential, which may cause tissue damage and development of pathogenesis in many inflammatory disorders. Here we review the characteristics of CD4<SUP>+</SUP>CD28<SUP>–</SUP> T cells as well as the recent advances highlighting the contribution of these cells to several disease conditions.
#CD28 #Co-stimulatory receptor #CD4+CD28– T cells #Chronic inflammatory diseases #Cytotoxic potential

Contents

INTRODUCTION
CD4+CD28- T-cell biology
Clinical Relevance of CD4+CD28- T cells
Concluding remarks
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UCI(KEPA) : I410-ECN-0101-2017-517-001848952