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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.6
- 수록면
- 1 - 15 (15page)
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초록· 키워드
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Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naïve to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.
목차
ABSTRACT
INTRODUCTION
MEMORY CD8+ T CELLS
CCR7-CHEMOKINE RECEPTOR FOR MEMORY CD8+ T CELLS
CCR7 PROVIDES IMPORTANT HOMING SIGNALS FOR MEMORY CD8+ T CELLS
CONCLUSION AND FUTURE PERSPECTIVES
REFERENCES
참고문헌 (100)
참고문헌 신청
Weninger W / 2001 / Migratory properties of naive, effector, and memory CD8+ T cells / J Exp Med 194:953~966
Butcher EC / 1999 / Lymphocyte trafficking and regional immunity / Adv Immunol 72:209~253
Campbell JJ / 2001 / CCR7 expression and memory T cell diversity in humans / J Immunol 166:877~884
Abdelsamed HA / 2017 / Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis / J Exp Med 214:1593~1606
Volkert M / 1974 / Twp populations of T lymphocytes immune to the lymphocytic choriomeningitis virus / J Exp Med 139:1329~1343
Butcher EC / 1999 / Lymphocyte trafficking and regional immunity / Adv Immunol 72:209~253
Campbell JJ / 2001 / CCR7 expression and memory T cell diversity in humans / J Immunol 166:877~884
Abdelsamed HA / 2017 / Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis / J Exp Med 214:1593~1606
Volkert M / 1974 / Twp populations of T lymphocytes immune to the lymphocytic choriomeningitis virus / J Exp Med 139:1329~1343
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UCI(KEPA) : I410-ECN-0101-2020-517-000894384