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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 608 - 614 (7page)
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초록· 키워드
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Purpose: We aimed to investigate clinical outcomes between top-down (TD) and conventional step-up (SU) therapies in pediatricpatients with moderate to severe ulcerative colitis (UC). Materials and Methods: All patients underwent clinical and endoscopic evaluation at diagnosis and 4 months and 1 year aftertreatment. Patients who started treatment with corticosteroid were grouped in the SU group, while those that initiated early infliximab(IFX) were grouped in the TD group. Among the SU group, patients who eventually changed to IFX treatment due to steroidresistance or dependency were included in the SU(R) group. Results: In total, 44 children with moderate to severe UC were included for analysis. Twenty-one patients were included in the SUgroup, 23 were included in the TD group, and 10 were enrolled in the SU(R) group. Relapse rates were 47.6% (10/21) in the SUgroup and 17.4% (4/23) in the TD group (p=0.033). Among relapsed patients, the durations from remission to relapse were 17.3months (0.9?46.9) in the SU group and 24.3 months (1.8?44.9) in the TD group. There was no statistically significant difference inthe sustained durations of remission after IFX administration between the SU(R) and TD groups [3.9 (1.4?6.3) and 2.3 (0.3?5.2)years, respectively (p>0.05)]. Conclusion: According to our study, early use of IFX without corticosteroid treatment for children with moderate to severe UChelps to lower relapse rates. We also found that IFX was a very effective treatment for pediatric UC, with a sustained duration ofremission similar between TD and SU(R) groups.
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참고문헌 (33)
참고문헌 신청
Kornbluth A / 2010 / Practice Parameters Committee of the American College of Gastroenterology. Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee / Am J Gastroenterol 105:501~523
Ordás I / 2012 / Ulcerative colitis / Lancet 380:1606~1619
Mowat C / 2011 / Guidelines for the management of inflammatory bowel disease in adults / Gut 60:571~607
Baldassano RN / 1999 / Inflammatory bowel disease in pediatric and adolescent patients / Gastroenterol Clin North Am 28:445~458
Dotson JL / 2010 / Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity / J Pediatr Gastroenterol Nutr 51:140~145
Ordás I / 2012 / Ulcerative colitis / Lancet 380:1606~1619
Mowat C / 2011 / Guidelines for the management of inflammatory bowel disease in adults / Gut 60:571~607
Baldassano RN / 1999 / Inflammatory bowel disease in pediatric and adolescent patients / Gastroenterol Clin North Am 28:445~458
Dotson JL / 2010 / Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity / J Pediatr Gastroenterol Nutr 51:140~145
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