지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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OBJECTIVES Tardive dyskinesia (TD) is a movement disorder that is characterized by hyperkinetic movements. Previous studies have suggested that the serotonergic systems are correlated with TD vulnerability. In this study, the association between a single-nucleotide polymorphism (SNP) of the serotonin 1A receptor gene (HTR1A) rs6295 and TD was investigated. METHODS We investigated whether HTR1A rs6295 SNP is associated with antipsychotic-induced TD in 280 Korean patients with schizophrenia. Patients with schizophrenia having TD (n=105) and those without TD (n=175) were matched for their antipsychotic exposures and other relevant variables. The HTR1A rs6295 SNP was analyzed using polymerase chain reaction (PCR)-based methods. RESULTS There was no significant difference in the distribution of genotypic (χ2=2.70, p=0.26) and allelic (χ2=1.87, p=0.17) frequencies between the patient groups with TD and without TD. There was no significant difference in total abnormal involuntary movement scale score (F=0.39, p=0.68) among the genotype group either. CONCLUSION Although there were no differences in genotypic and allelic frequency between patient groups with and without TD, further studies on association of TD with other SNPs of HTRA1 are needed to understand the pathophysiological mechanism of TD.
목차
등록된 정보가 없습니다.
참고문헌 (53)
참고문헌 신청
Woods SW / 2010 / Incidence of tardive dyskinesia with atypical versus conventional antipsychotic medications : a prospective cohort study / J Clin Psychiatry 71:463~474
Stegmayer K / 2018 / Tardive dyskinesia associated with atypical antipsychotics: prevalence, mechanisms and management strategies / CNS Drugs 32:135~147
Casey DE / 1991 / Neuroleptic drug-induced extrapyramidal syndromes and tardive dyskinesia / Schizophr Res 4:109~120
Frei K / 2019 / Tardive dyskinesia : who gets it and why / Parkinsonism Relat Disord 59:151~154
Muller DJ / 2001 / Familial occurrence of tardive dyskinesia / Acta Psychiatr Scand 104:375~379
Stegmayer K / 2018 / Tardive dyskinesia associated with atypical antipsychotics: prevalence, mechanisms and management strategies / CNS Drugs 32:135~147
Casey DE / 1991 / Neuroleptic drug-induced extrapyramidal syndromes and tardive dyskinesia / Schizophr Res 4:109~120
Frei K / 2019 / Tardive dyskinesia : who gets it and why / Parkinsonism Relat Disord 59:151~154
Muller DJ / 2001 / Familial occurrence of tardive dyskinesia / Acta Psychiatr Scand 104:375~379
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