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논문 기본 정보

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학술저널
저자정보
Eirini Theodoraki (Department of Gastroenterology University Hospital of Heraklion) Eleni Orfanoudaki (Department of Gastroenterology University Hospital of Heraklion) Kalliopi Foteinogiannopoulou (Department of Gastroenterology University Hospital of Heraklion) Evangelia Legaki (National and Kapodistrian University of Athens Medical School) Maria Gazouli (National and Kapodistrian University of Athens Medical School) Ioannis E. Koutroubakis (Department of Gastroenterology University Hospital of Heraklion)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.19 No.4
발행연도
2021.10
수록면
461 - 467 (7page)
DOI
10.5217/ir.2020.00042

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Background/Aims: The measurement of infliximab trough levels (IFX-TLs) in patients with inflammatory bowel disease (IBD) is performed to optimize treatment. However, the association between the development of adverse events (AEs) and IFX-TLs has not been sufficiently studied thus far. To investigate the possible association of IFX-TLs with AEs in Greek patients with IBD receiving maintenance treatment with IFX.Methods: A retrospective analysis of the registry data of the Gastroenterology Department of the University Hospital of Heraklion, from IBD patients with at least one available IFX-TL measurement during the years 2016 to 2017 was conducted. AEs reported 4 months before and 4 months after the measured IFX-TLs were recorded. The IFX-TLs of patients with or without AEs were compared.Results: Of a total of 83 IBD patients (61 Crohn’s disease [73%]; 52 men [63%]; mean age ± standard deviation, 43.3 ± 16.0 years), 147 measurements of IFX-TLs were available (median 4.69 μg/ mL [1.32?9.16]), and 99 AEs (67.3%, 14 severe) were registered. The median IFX-TL of patients with AEs was 5.79 μg/mL (1.36? 10.25), higher than the median IFX-TL of patients without AEs (3.40 μg/mL [1.30?5.92]), but the difference was not significant (P= 0.97). The presence of infections or dermatologic reactions was not correlated with IFX-TLs. There was no difference in the prevalence of the total AEs (66.7% vs. 73.3%, P= 0.77) or in the analysis of AEs by group between patients with IFX-TLs ≥ 15 μg/ mL and patients with IFX-TLs < 15 μg/mL.Conclusions: IFX-TLs are not significantly associated with the development of AEs in IBD patients receiving maintenance treatment with IFX.
#Adverse drug events #Crohn disease #Infliximab #Infections #Colitis #ulcerative

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참고문헌 (20)

참고문헌 신청
Schnitzler F / 2009 / Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn’s disease / Inflamm Bowel Dis 15:1295~1301 google schola Colombel JF / 2009 / Comparison of two adalimumab treatment schedule strategies for moderate-to-severe Crohn’s disease: results from the CHARM trial / Am J Gastroenterol 104:1170~1179 google schola Papamichael K / 2019 / Infliximab in inflammatory bowel disease / Ther Adv Chronic Dis 10:2040622319838443 google schola van Hoeve K / 2018 / Higher infliximab trough levels are associated with better outcome in paediatric patients with inflammatory bowel disease / J Crohns Colitis 12:1316~1325 google schola Hoentjen F / 2009 / Safety of anti-tumor necrosis factor therapy in inflammatory bowel disease / World J Gastroenterol 15:2067~2073 google schola

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