지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 858 - 866 (9page)
- DOI
- 10.5009/gnl20294
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초록· 키워드
오류제보하기
Background/Aims: Few studies have investigated terminal ileal lesions and their prognostic value in patients with ulcerative colitis (UC). We evaluated the clinical significance of these lesions as a prognostic factor in patients with UC who were in clinical remission.
Methods: We retrospectively selected 567 of 4,066 colonoscopy reports that included positive findings from orificial observations of the terminal ileum (TI) and appendix in patients with UC. We finally recruited patients who were in clinical remission (n=204). We compared the clinical courses, including relapse and other prognostic parameters associated with UC, between the groups.
Results: The baseline patient characteristics were not significantly different between patients with (n=69, TI+ group) and without TI lesions (n=135, TI? group), although there were more never-smokers in the TI+ group (n=57 [82.6%] in the TI+ group; n=86 [63.7%] in the TI? group; p=0.005). Of note, appendiceal orifice inflammation (AOI) was less frequently found in the TI+ group (14.5%) than in the TI? group (71.9%, p<0.001). The cumulative relapse rate was numerically higher in the TI? group, but it was not significantly different according to the Kaplan-Meier analysis (p=0.116). Multivariate Cox regression analysis also revealed advanced age at diagnosis as the most significant factor (adjusted hazard ratio, 0.964; 95% confidence interval, 0.932 to 0.998; p=0.037), but neither TI inflammation nor AOI were significantly associated with the cumulative relapse rate in patients with UC in clinical remission.
Conclusions: For patients with UC in clinical remission, neither terminal ileal lesions nor AOI had significant clinical or predictive value for future relapse.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
McGovern DP / 2010 / Genome-wide association identifies multiple ulcerative colitis susceptibility loci / Nat Genet 42:332~337
Cleynen I / 2016 / Inherited determinants of Crohn’s disease and ulcerative colitis phenotypes : a genetic association study / Lancet 387:156~167
Triantafillidis JK / 2011 / Current and emerging drugs for the treatment of inflammatory bowel disease / Drug Des Devel Ther 5:185~210
Kim B / 2014 / Proximal disease extension and related predicting factors in ulcerative proctitis / Scand J Gastroenterol 49:177~183
Lee HJ / 2012 / Long-term clinical outcomes and factors predictive of relapse after 5-aminosalicylate or sulfasalazine therapy in patients with mild-to-moderate ulcerative colitis / Hepatogastroenterology 59:1415~1420
Cleynen I / 2016 / Inherited determinants of Crohn’s disease and ulcerative colitis phenotypes : a genetic association study / Lancet 387:156~167
Triantafillidis JK / 2011 / Current and emerging drugs for the treatment of inflammatory bowel disease / Drug Des Devel Ther 5:185~210
Kim B / 2014 / Proximal disease extension and related predicting factors in ulcerative proctitis / Scand J Gastroenterol 49:177~183
Lee HJ / 2012 / Long-term clinical outcomes and factors predictive of relapse after 5-aminosalicylate or sulfasalazine therapy in patients with mild-to-moderate ulcerative colitis / Hepatogastroenterology 59:1415~1420
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