지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 541 - 548 (8page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Infliximab (IFX) often loses its therapeutic effect in initial responders with inflammatory bowel disease (IBD) over time. Low serum IFX trough levels (TLs) are linked to poor clinical response and outcomes. Maintenance of optimal therapeutic IFX concentrations is important for sustaining response and achieving good clinical outcomes. Measurement of serum IFX TLs is helpful for determining a further proper therapeutic plan. However, adequate therapeutic IFX TLs in pediatric IBD is uncertain. We aimed to identify the cutoff values for IFX TLs associated with laboratory response to IFX maintenance therapy. Methods: Patients with pediatric IBD who had received IFX infusions between December 2008 and March 2015 at Samsung Medical Center were retrospectively investigated. We analyzed 239 blood samples that were collected from 103 pediatric patients. We measured IFX TLs at induction (6 and 14 weeks) and during maintenance therapy (>22 weeks, 8 weeks interval) by fluid-phase radioimmunoassays. Results: A significant association was found between the erythrocyte sedimentation rate (ESR) and IFX TLs during maintenance (correlation coefficient, –0.11; p=0.0005). A cutoff value of 18 mm/hr for ESR was used to define higher levels. Receiver operating characteristic analysis identified optimal cutoff values: IFX TL >1.58 µg/mL (sensitivity 82% and specificity 73%). Conclusions: Cutoff values are considered a prerequisite for further investigating the clinical usefulness of measurements of IFX in patients maintained with IFX treatment.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Xavier RJ / 2007 / Unravelling the pathogenesis of inflammatory bowel disease / Nature 448:427~434
Kim SC / 2004 / Inflammatory bowel diseases in pediatric and adolescent patients : clinical, therapeutic, and psychosocial considerations / Gastroenterology 126:1550~1560
서정기 / 2011 / 소아기에 발병하는 염증성장질환(IBD)은 성인 IBD와 다른 질환인가? - 조기발병 소아 IBD의 역학적, 임상적, 유전학적 특성 및 치료 시 고려 사항- / Pediatric Gastroenterology, Hepatology & Nutrition 14(1):1~25
Langholz E / 1997 / Inflammatory bowel diseases with onset in childhood : clinical features, morbidity, and mortality in a regional cohort / Scand J Gastroenterol 32:139~147
Guariso G / 2010 / Inflammatory bowel disease developing in paediatric and adult age / J Pediatr Gastroenterol Nutr 51:698~707
Kim SC / 2004 / Inflammatory bowel diseases in pediatric and adolescent patients : clinical, therapeutic, and psychosocial considerations / Gastroenterology 126:1550~1560
서정기 / 2011 / 소아기에 발병하는 염증성장질환(IBD)은 성인 IBD와 다른 질환인가? - 조기발병 소아 IBD의 역학적, 임상적, 유전학적 특성 및 치료 시 고려 사항- / Pediatric Gastroenterology, Hepatology & Nutrition 14(1):1~25
Langholz E / 1997 / Inflammatory bowel diseases with onset in childhood : clinical features, morbidity, and mortality in a regional cohort / Scand J Gastroenterol 32:139~147
Guariso G / 2010 / Inflammatory bowel disease developing in paediatric and adult age / J Pediatr Gastroenterol Nutr 51:698~707
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