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논문 기본 정보

자료유형
학술저널
저자정보
이지혜 (연세대학교) 이광현 (국민건강보험공단 일산병원) 성공제 (연세대학교) 김찬윤 (연세대학교) Sang Yeop Lee (연세대학교) 배형원 (연세대학교)
저널정보
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제34권 제4호
발행연도
2020.1
수록면
322 - 333 (12page)

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Purpose: This study aimed to compare the clinical characteristics of patients who showed structural progression in the peripapillaryretinal nerve fiber layer (RNFL) first against those who showed progression in the macular ganglion cell-inner plexiformlayer (GCIPL) first and to investigate clinical parameters that help determine whether a patient exhibits RNFL or GCIPLdamage first. Methods: A retrospective review of medical records of patients diagnosed with early-stage normal-tension glaucoma wasperformed. All eyes underwent intraocular pressure measurement with Goldmann applanation tonometer, standard automatedperimetry, and Cirrus optical coherence tomography at 6-month intervals. Structural progression was determinedusing the Guided Progression Analysis software. Blood pressure was measured at each visit. Results: Forty-one eyes of 41 patients (mean age, 52.6 ± 16.7 years) were included in the study. In 21 eyes, structural progressionwas first detected in the RNFL at 54.2 ± 14.8 months, while structural progression was first observed at the macularGCIPL at 40.5 ± 11.0 months in 20 eyes. The mean intraocular pressure following treatment was 13.1 ± 1.8 mmHg for theRNFL progression first group and 13.4 ± 1.8 mmHg for the GCIPL progression first group (p = 0.514). The GCIPL progressionfirst group was older (p = 0.008) and had thinner RNFL at baseline (p = 0.001). The logistic regression analyses indicated thatboth age and follow-up duration until first progression predicted the region of structural progression (odds ratio, 1.051; 95%confidence interval, 1.001?1.105; p = 0.046 for age; odds ratio, 0.912; 95% confidence interval, 0.840?0.991; p = 0.029 fortime until progression). Conclusions: Age of glaucoma patients and time until progression are associated with the region of the first structural progressionin normal-tension glaucoma. Further studies exploring the association between glaucomatous progression and thelocation of damage are needed.

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