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학술저널
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대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제30권 제6호
발행연도
2016.1
수록면
451 - 458 (8page)

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Purpose: To investigate the use of ganglion cell inner plexiform layer (GC-IPL) thickness, as measured by spectraldomain optical coherence tomography, to detect central visual field (VF) progression. Methods: This study included 384 eyes from 384 patients (219 preperimetric and 165 perimetric glaucomatouseyes; average follow-up, 4.3 years). Photographic assessment of retinal nerve fiber layer (RNFL) and serialVF analysis were performed to detect glaucoma progression in the central (within 10°) area. Study inclusionrequired at least five serial spectral domain optical coherence tomography exams at different visits. Thelong-term test-retest variability of average GC-IPL thicknesses was calculated in 110 stable preperimetricglaucomatous eyes. The sensitivity and specificity of GC-IPL measurements for the detection of central VFprogression were calculated in an event-based analysis using the calculated variability as a cut-off and werecompared with those of central RNFL photographic assessment. Results: The intersession test-retest variability, defined as the 95% confidence interval, was 1.76 μm for averageGC-IPL thickness. The sensitivity and specificity of the average GC-IPL thickness for detecting central VFprogression were 60.7% and 78.9%, respectively. Among six sectors, the inferonasal GC-IPL sector showedthe highest sensitivity (53.6%). The sensitivity of the ≥1 sector GC-IPL to detect central VF progression wassignificantly higher than that of central RNFL photographic progression (p = 0.013). Other GC-IPL parametersshowed comparable sensitivity and specificity to detect central VF progression compared with RNFL photographicprogression. Conclusions: Serial GC-IPL measurements show comparable performance in the detection of central glaucomatousVF progression to RNFL photographic assessment.

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