지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective. Ankylosing spondylitis (AS) is a chronic inflammatory disease with obvious male preponderance. Males show more severe radiographic manifestations compared with females. This study aimed to evaluate the effects of sex and estrogen on the radiographic progression of AS. Methods. A total of 101 patients with AS were included in this study. All of the radiographs were scored using the modified Stoke AS Spine Score (mSASSS). Serum levels of 17β-estradiol (E2), dickkopf-1 (Dkk1), and leptin were detected by enzyme-linked immunosorbent assay. The generalized estimating equations model was used to evaluate factors associated with spinal radiographic progression. Results. The mean age at disease onset was 27.3±10.7 years, and 16 patients (15.8%) were female. In the multivariable analysis, body mass index (β-coefficient=0.12; p=0.047) and levels of Dkk1 (β-coefficient=−0.11; p＜0.001), and female (β-coefficient=−1.40; p=0.001) were associated with radiographic progression. Among male patients with AS, baseline C-reactive protein (β=0.11; p=0.005) and mSASSS (β=0.21; p=0.030) were also associated with radiographic progression. E2 and leptin levels were not significantly related to the radiographic progression. Conclusion. Although female patients were associated with less radiographic progression in AS, there was no significant relationship between serum estrogen level and radiographic progression. Results of current study suggests that genetic factors or other environmental factors associated with female may influence radiographic progression in patients with AS.
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참고문헌 (40)
참고문헌 신청
Lee W / 2007 / Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort / Ann Rheum Dis 66:633~638
Will R / 1990 / Is there sexual inequality in ankylosing spondylitis? A study of 498 women and 1202 men / J Rheumatol 17:1649~1652
Jeong H / 2015 / Clinical characteristics of nonradiographic axial spondyloarthritis in Korea : a comparison with ankylosing spondylitis / Int J Rheum Dis 18:661~668
Kobak S / 2013 / Coexistence of ankylosing spondylitis and Klinefelter's syndrome / Case Rep Rheumatol 2013:543953
Armstrong RD / 1985 / Ankylosing spondylitis and Klinefelter's syndrome : does the X chromosome modify disease expression / Br J Rheumatol 24:277~281
Will R / 1990 / Is there sexual inequality in ankylosing spondylitis? A study of 498 women and 1202 men / J Rheumatol 17:1649~1652
Jeong H / 2015 / Clinical characteristics of nonradiographic axial spondyloarthritis in Korea : a comparison with ankylosing spondylitis / Int J Rheum Dis 18:661~668
Kobak S / 2013 / Coexistence of ankylosing spondylitis and Klinefelter's syndrome / Case Rep Rheumatol 2013:543953
Armstrong RD / 1985 / Ankylosing spondylitis and Klinefelter's syndrome : does the X chromosome modify disease expression / Br J Rheumatol 24:277~281
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