지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제6호
- 발행연도
- 2021.1
- 수록면
- 784 - 793 (10page)
이용수
초록· 키워드
오류제보하기
Previous studies have uncovered the role of circ_0000144 in various tumors. Here, we investigated the function and mechanism of circ_0000144 in gastric cancer (GC) progression. The expression of circ_0000144 in GC tissues and cells was detected through quantitative real-time polymerase chain reaction (qRT-PCR) method. Gain- and loss-of-function experiments including colony formation, wound healing and transwell assays were performed to examine the role of circ_0000144 in GC cells. Furthermore, western blot was conducted to determine the expressions of epithelial mesenchymal transition (EMT)-related proteins. The interaction between circ_0000144 and miR-217 was analyzed by bioinformatic analysis and luciferase reporter assays. The circ_0000144 expression was obviously upregulated in GC tissues and cells. Silencing of circ_0000144 inhibited cell proliferation, migration and invasion of GC cells, but ectopic expression of circ_0000144 showed the opposite results. Moreover, circ_0000144 sponged miR-217, and rescue assays revealed that silencing miR-217 expression reversed the inhibitory effect of circ_0000144 knockdown on the progress of GC. Our findings reveal that circ_0000144 inhibition suppresses GC cell proliferation, migration and invasion via absorbing miR-217, providing a new biomarker and potential therapeutic target for treatment of GC
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Choi IJ / 2018 / Helicobacter pylori therapy for the prevention of metachronous gastric cancer / N. Engl. J. Med 378:1085~1095
Choi YY / 2017 / Beyond precision surgery : molecularly motivated precision care for gastric cancer / Eur. J. Surg. Oncol 43:856~864
Dai X / 2018 / Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation / Cell Death Dis 9:454
Figueiredo C / 2015 / Pathogenesis of gastric cancer / Helicobacter 20(Suppl):30~35
Huang W / 2018 / Downregulation of circular RNA hsa_circ_0000144 inhibits bladder cancer progression via stimulating miR-217 and suppressing RUNX2 expression / Gene 678:337~342
Choi YY / 2017 / Beyond precision surgery : molecularly motivated precision care for gastric cancer / Eur. J. Surg. Oncol 43:856~864
Dai X / 2018 / Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation / Cell Death Dis 9:454
Figueiredo C / 2015 / Pathogenesis of gastric cancer / Helicobacter 20(Suppl):30~35
Huang W / 2018 / Downregulation of circular RNA hsa_circ_0000144 inhibits bladder cancer progression via stimulating miR-217 and suppressing RUNX2 expression / Gene 678:337~342
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hsa_Circ_0001947/MiR-661/DOK7 Axis Restrains Non-Small Cell Lung Cancer Development
Journal of Microbiology and Biotechnology
2021 .11
-
Circ_0001666 affects miR-620/WNK2 axis to inhibit breast cancer progression
Genes & Genomics
2021 .08
-
Mmu_circ_0000271 regulated the growth of ox-LDL-stimulated mouse vascular smooth muscle cells via sponging miR-5123
Genes & Genomics
2022 .09
-
MiR-1299 functions as a tumor suppressor to inhibit the proliferation and metastasis of gastric cancer by targeting ARF6
Genes & Genomics
2022 .02
-
CircRNA circ_0067772 aggravates the malignant progression of cutaneous squamous cell carcinoma by regulating miR-1238-3p/FOXG1 axis
Genes & Genomics
2021 .01
-
miRNA-103a-3p Promotes Human Gastric Cancer Cell Proliferation by Targeting and Suppressing ATF7 in vitro
Molecules and Cells
2018 .03
-
Circ_UBE2D2 Attenuates the Progression of Septic Acute Kidney Injury in Rats by Targeting miR-370-3p/NR4A3 Axis
Journal of Microbiology and Biotechnology
2022 .06
-
CircRNA_OTUD7A upregulates FOXP1 expression to facilitate the progression of diffuse large B-cell lymphoma via acting as a sponge of miR-431-5p
Genes & Genomics
2021 .01
-
MicroRNA?9 inhibits proliferation and progression in retinoblastoma cells by targeting PTEN
Genes & Genomics
2021 .09
-
CircCOL1A2 Sponges MiR-1286 to Promote Cell Invasion and Migration of Gastric Cancer by Elevating Expression of USP10 to Down-regulate RFC2 Ubiquitination Level
Journal of Microbiology and Biotechnology
2022 .07
-
MiR-200c-3p aggravates gastric cell carcinoma via KLF6
Genes & Genomics
2021 .11
-
Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer
Genomics & informatics
2015 .01
-
MicroRNA‑377‑3p inhibits growth and invasion through sponging JAG1 in ovarian cancer
Genes & Genomics
2019 .01
-
Bacillus spp.를 이용한 옥수수 밑둥썩음병의 생물학적 방제
Research in Plant Disease(식물병연구)
2015 .12
-
LncRNA H19 Drives Proliferation of Cardiac Fibroblasts and Collagen Production via Suppression of the miR-29a-3p/miR-29b-3p-VEGFA/TGF-β Axis
Molecules and Cells
2022 .03
-
MicroRNA-576-3p Inhibits Proliferation in Bladder Cancer Cells by Targeting Cyclin D1
Molecules and Cells
2015 .02
-
Suppression of HELLS by miR-451a represses mTOR pathway to hinder aggressiveness of SCLC
Genes & Genomics
2021 .01
-
miR-30a Regulates the Expression of CAGE and p53 and Regulates the Response to Anti-Cancer Drugs
Molecules and Cells
2016 .04
-
GC/FID와 GC/MS 분석법에 의한 토양 페놀의 분석 특성 비교
한국분석과학회 학술대회
2015 .11
-
Overexpression of Long Non-Coding RNA MIR22HG Represses Proliferation and Enhances Apoptosis via miR-629-5p/TET3 Axis in Osteosarcoma Cells
Journal of Microbiology and Biotechnology
2021 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0