MicroRNA 449c Mediates the Generation of Monocytic Myeloid-Derived Suppressor Cells by Targeting STAT6

Xiaoqing Han; Tao Luan; Yingying Sun; Wenyi Yan; Dake Wang; Xianlu Zeng

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자료유형: 학술저널

저자정보: Xiaoqing Han (Northeast Normal University) Tao Luan (Northeast Normal University) Yingying Sun (Northeast Normal University) Wenyi Yan (Northeast Normal University) Dake Wang (Northeast Normal University) Xianlu Zeng (Northeast Normal University)

저널정보: 한국분자세포생물학회 Molecules and Cells Molecules and Cells 제43권 제9호

발행연도: 2020.1

수록면: 793 - 803 (11page)

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Myeloid-derived suppressor cells (MDSCs) promote tumour progression by contributing to angiogenesis, immunosuppression, and immunotherapy resistance. Although recent studies have shown that microRNAs (miRNAs) can promote the expansion of MDSCs in the tumour environment, the mechanisms involved in this process are largely unknown. Here, we report that microRNA 449c (miR-449c) expression was upregulated in myeloid progenitor cells upon activation of C-X-C motif chemokine receptor 2 (CXCR2) under tumour conditions. MiR-449c upregulation increased the generation of monocytic MDSCs (mo-MDSCs). The increased expression of miR-449c could target STAT6 mRNA in myeloid progenitor cells to shift the differentiation balance of myeloid progenitor cells and lead to an enhancement of the mo-MDSCs population in the tumour environment. Thus, our results demonstrate that the miR-449c/STAT6 axis is involved in the expansion of mo-MDSCs from myeloid progenitor cells upon activation of CXCR2, and thus, inhibition of miR-449c/STAT6 signalling may help to attenuate tumour progression.

#C-X-C motif chemokine receptor 2 #differentiation #microRNA 449c #mo-MDSCs #STAT6

참고문헌 (40)

참고문헌 신청

Bartel, D. P / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297

Chatterjee, S. / 2013 / Myeloid derived suppressor cells(MDSCs)can induce the generation of Th17 response from naive CD4+ T cells / Immunobiology 218:718~724

Chen, S. / 2015 / Regulating tumor myeloid-derived suppressor cells by microRNAs / Cancer Cell Microenviron 2:e637

Chen, X. / 2018 / miR-449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3 / Oncol. Lett 16:417~424

Chomarat, P. / 2000 / IL-6 switches the differentiation of monocytes from dendritic cells to macrophages / Nat. Immunol 1:510~514

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