A randomized controlled trial to compare the efficacy of regenerated and non-regenerated oxidized cellulose gauze for the secondary treatment of local bleeding in patients undergoing hepatic resection

Chengshuo Zhang; Dazhi Fu; Fengshan Wang; Xinping Zhong; Lei Yang; Gang Wu; Baifeng Li; Jialin Zhang

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자료유형: 학술저널

저자정보: Chengshuo Zhang (The First Hospital of China Medical) Dazhi Fu (The First Hospital of China Medical) Fengshan Wang (The First Hospital of China Medical) Xinping Zhong (The First Hospital of China Medical) Lei Yang (The First Hospital of China Medical) Gang Wu (The First Hospital of China Medical) Baifeng Li (The First Hospital of China Medical) Jialin Zhang (The First Hospital of China Medical)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.100 No.4

발행연도: 2021.4

수록면: 193 - 199 (7page)

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Purpose: Oxidized cellulose is available in many forms, but manufactured using either a regenerated or non-regenerated process. In this study, we evaluated the effects of 2 different hemostatic agents for the treatment of local bleeding in patients undergoing hepatic resection.
Methods: This was a monocentric, parallel-group, randomized, and controlled clinical trial to compare oxidized regenerated cellulose gauze (ORCG) with oxidized non-regenerated cellulose gauze (ONRCG) in patients undergoing hepatectomy. The primary endpoint was the time to hemostasis at the target bleeding site. The secondary endpoints were the postoperative drainage volume on the first 2 days after surgery and the hospital stay.
Results: There was no significant difference between the ORCG and ONRCG groups in time to hemostasis from column analysis (238.8 ± 121.6 seconds vs. 193.7 ± 85.3 seconds, P = 0.068), and there were no differences in the rates of hemostatic success between the 2 groups at 120 seconds (18.4% vs. 24.3%; odds ratio [OR], 0.703; 95% confidence interval [CI], 0.231–2.136) and 300 seconds (71.1% vs. 89.2%; OR, 0.298; 95% CI, 0.085–1.041). However, the ONRCG group was superior to the ORCG group in hemostasis according to the survival analysis (log-rank test, P = 0.044). Moreover, there were also no significant differences between the 2 groups in postoperative drainage volume on the first 2 days (P = 0.436, P = 0.381) and hospital stay (P = 0.537, P = 0.200).
Conclusion: ONRCG was not inferior to ORCG as a hemostatic agent in patients undergoing liver resection.

#Hepatectomy #Hemostasis #Oxidized cellulose #Surgicel #Traumastem

참고문헌 (23)

참고문헌 신청

Kubo S / 2007 / Risk factors for massive blood loss during liver resection for hepatocellular carcinoma in patients with cirrhosis / Hepatogastroenterology 54:830~833

Lei Z / 2012 / Exploration on surgicalrelated factors influencing HCC patients prognosis / Hepatogastroenterology 59:1541~1543

Harada N / 2015 / Blood transfusion is associated with recurrence of hepatocellular carcinoma after hepatectomy in Child-Pugh class A patients / World J Surg 39:1044~1051

Li Z / 2014 / Controlled low central venous pressure reduces blood loss and transfusion requirements in hepatectomy / World J Gastroenterol 20:303~309

Lau WY / 2010 / Methods of vascular control technique during liver resection: a comprehensive review / Hepatobiliary Pancreat Dis Int 9:473~481

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