지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 347 - 356 (10page)
- DOI
- https://doi.org/10.1186/s40824-021-00239-1
이용수
초록· 키워드
오류제보하기
Background: Medical hemostatic biological materials are necessary for the development of the process of preventing and stopping damaged intravascular bleeding. In the process, some red blood cells and white blood cells are trapped in nets. The resulting plug is called a blood clot. This is often a good step in wound healing, but separation of blood clots from blood vessel walls can cause serious health problems. Main body: The advance in the development of hemostatic biomaterials is necessary for biomedical application. Firstly, the historical background of artificial hemostasis has been included and the current research of hemostasis has been included in more detail. Secondly, the current research of hemostasis has been included on the oxidized cellulose-based hemostatic biomaterials such as starch based on composite cross-linking hemostatic networks, hemostatic materials on NHS-esters, hemostatic agent from local materials and biomaterials for hemostatic management. Thirdly, polysaccharide hemostatic materials, bio-inspired adhesive catechol-conjugated chitosan, mesoporous silica and bioactive glasses for improved hemostasis, minimally invasive hemostatic biomaterials and chitosan-base materials for hemostatic application have been included. Fourthly, the biological properties of natural hemostatic agent by plasma technology and the hemostatic agents based on gelatin microbial transglutaminase mixes have been also included. Conclusion: Current research on hemostasis includes hemostatic biomaterials such as cellulose-based hemostatic starch based on a complex cross-linked hemostatic network. It also includes polysaccharide hemostatic materials, biomimetic adhesive catechol-binding chitosan, mesoporous silica or physiologically active glass for hemostatic improvement, minimally invasive hemostatic chitosan-based materials, and gelatin-microbial transglutaminase-based hemostatic agents. Future studies should focus on modular combination of hemostatic imitation and reinforcement mechanisms of different materials and technologies to find the optimal system to promote and strengthen active platelet or platelet imitation aggregation in bleeding sites. The second optionally increases the production of thrombin and fiber formation at the site. Third, the formed fibrin biopolymer network has strengthened to reduce thrombosis and amplify hemostasis.
목차
등록된 정보가 없습니다.
참고문헌 (70)
참고문헌 신청
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Burgaud JL / 2002 / Nitric oxide-releasing drugs : a novel class of effective and safe therapeutic agents / Ann N Y Acad Sci 962(1):360~371
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Shahidi, M / 2017 / Thrombosis and von Willebrand Factor / Adv. Exp. Med. Biol 906:285~306
Burgaud JL / 2002 / Nitric oxide-releasing drugs : a novel class of effective and safe therapeutic agents / Ann N Y Acad Sci 962(1):360~371
Cawello, W / 1994 / Metabolism and pharmacokinetics of prostaglandin E1 administered by intravenous infusion in human subjects / Eur J Clinical Pharmaco 46(3):275~277
Sadler J. E. / 1998 / Biochemistry and genetics of von Willebrand factor / Annu Rev Biochem 67:395~424
Shahidi, M / 2017 / Thrombosis and von Willebrand Factor / Adv. Exp. Med. Biol 906:285~306
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