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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.8
- 수록면
- 102 - 109 (8page)
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초록· 키워드
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Backgrounds/Aims: This study evaluated the hemostatic effects of a novel oxidized regenerated cellulose, SurgiGuard<SUP>®</SUP>, during liver surgery, using a reproducible and clinically relevant animal model. Methods: Fifteen mini-pigs underwent left partial hepatectomy. They were randomized to treatment of the resected surface with SurgiGuard<SUP>®</SUP> (Group C [test], n=5), Surgicel<SUP>®</SUP> (Group B [reference], n=5), or nothing (Group A [control], n=5). Blood loss was measured 5, 7 and 9 min after resection. Time to hemostasis was recorded. Mini-pigs were necropsied 4 or 6 weeks postoperatively to evaluate toxicity changes and material dissolution. Results: The median resected liver weight was 2.13 g (2.02-2.20) in control group, 2.04 g (2.01-2.13) in reference group, and 2.01 g (1.99-2.12) in test group (p=0.024). Median total blood loss was 57.18 g (52.02-59.54) in control group, 32.52 g (27.66-35.10) in reference group, and 35.52 g (25.70-38.71) in test group (p=0.008). Blood loss at 0-5 minutes and 7-9 minutes was significantly different between groups (p=0.009 and p=0.006, respectively). At necropsy, no hematomas, granulomas, or adhesions were noted in any group. Histopathological analysis revealed no changes suggesting toxicity related to SurgiGuard<SUP>®</SUP>. Conclusions: SurgiGuard<SUP>®</SUP> is as effective as Surgicel<SUP>®</SUP> in achieving hemostasis after porcine partial liver resection.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2017-514-000982887