지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.99 No.6
- 발행연도
- 2020.12
- 수록면
- 337 - 343 (7page)
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초록· 키워드
오류제보하기
Purpose: The aim of this study was to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR) in acute cellular rejection (ACR) after living donor liver transplantation (LDLT).
Methods: All consecutive patients who underwent ABO-compatible (ABOc) LDLT from September 2014 to December 2017 were retrospectively reviewed. NLR was calculated on 3 occasions; (1) 4 weeks prior to liver transplantation (LT), (2) the day of LT, and (3) the day before liver biopsy.
Results: Among 66 patients who underwent ABOc LDLT, ACR was identified in 15 patients (22.7%) on protocol liver biopsy performed routinely on the postoperative day 7. There was no significant difference in NLR at 4 weeks prior to LT and the day of LT between no-ACR and ACR group (2.98 ± 1.92 vs. 2.54 ± 1.15, P = 0.433; 17.9 ± 8.31 vs. 20.5 ± 13.4, P = 0.393). However, NLR was significantly lower in ACR group compared to non-ACR group just prior to liver biopsy (5.82 ± 3.42 vs. 18.4 ± 17.2, P = 0.035). NLR tends to decrease 3.5 days before the onset of ACR. The area under the receiver operating characteristic curve for optimal cut-off value of NLR was 6.49, with sensitivity and specificity of 80.4% and 73.3% respectively.
Conclusion: NLR has a potential as a noninvasive predictor of early ACR in ABOc LDLT.
Methods: All consecutive patients who underwent ABO-compatible (ABOc) LDLT from September 2014 to December 2017 were retrospectively reviewed. NLR was calculated on 3 occasions; (1) 4 weeks prior to liver transplantation (LT), (2) the day of LT, and (3) the day before liver biopsy.
Results: Among 66 patients who underwent ABOc LDLT, ACR was identified in 15 patients (22.7%) on protocol liver biopsy performed routinely on the postoperative day 7. There was no significant difference in NLR at 4 weeks prior to LT and the day of LT between no-ACR and ACR group (2.98 ± 1.92 vs. 2.54 ± 1.15, P = 0.433; 17.9 ± 8.31 vs. 20.5 ± 13.4, P = 0.393). However, NLR was significantly lower in ACR group compared to non-ACR group just prior to liver biopsy (5.82 ± 3.42 vs. 18.4 ± 17.2, P = 0.035). NLR tends to decrease 3.5 days before the onset of ACR. The area under the receiver operating characteristic curve for optimal cut-off value of NLR was 6.49, with sensitivity and specificity of 80.4% and 73.3% respectively.
Conclusion: NLR has a potential as a noninvasive predictor of early ACR in ABOc LDLT.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
Maluf DG / 2005 / Adult living donor versus deceased donor liver transplantation : a 6-year single center experience / Am J Transplant 5:149~156
Gruttadauria S / 2005 / Basiliximab in a triple-drug regimen with tacrolimus and steroids in liver transplantation / Transplant Proc 37:2611~2613
Emond JC / 1987 / Rejection in liver allograft recipients : clinical characterization and management / Clin transplant 1:143~150
Soin AS / 1995 / CsA levels in the early posttransplant period: predictive of chronic rejection in liver transplantation? / Transplantation 59:1119~1123
Neil DA / 2001 / Delay in diagnosis : a factor in the poor outcome of late acute rejection of liver allografts / Transplant Proc 33:1525~1526
Gruttadauria S / 2005 / Basiliximab in a triple-drug regimen with tacrolimus and steroids in liver transplantation / Transplant Proc 37:2611~2613
Emond JC / 1987 / Rejection in liver allograft recipients : clinical characterization and management / Clin transplant 1:143~150
Soin AS / 1995 / CsA levels in the early posttransplant period: predictive of chronic rejection in liver transplantation? / Transplantation 59:1119~1123
Neil DA / 2001 / Delay in diagnosis : a factor in the poor outcome of late acute rejection of liver allografts / Transplant Proc 33:1525~1526
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