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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Objectives: We performed this study to evaluate the antioxidative and hypolipidemic effect of Artemisia iwayomogi(韓茵蔯), Curcuma longa L. (鬱金) and Raphanus sativus L. (蘿葍子) (ACR).
Method: We enriched Artemisiae Capillaris, Curcumae Longae and Raphani Semen compound with alcohol. ACR extract is treated to HepG2 cell. Cell groups are devided into 3 groups: normal, control and ACR treated group. We measured polyphenol, flavonoids, DPPH and ABTS radical scavenging activity, ROS, glutathione, GSH peroxidase, GSH reductase, SOD, catalase, free fatty acid, lipid peroxidation and suppression of ACAT1 and HMG-CoA reductase expression on mRNA level.
Results:
1. ACR contained polyphenol and flavonoids and increased GSH significantly in HepG2 cell.
2. ACR increased GPx, GR, and catalase activity significantly in HepG2 cell.
3. ACR increased DPPH and ABTS radical scavenging activity significantly in HepG2 cell and decreased ROS.
4. ACR decreased free fatty acid and MDA significantly in HepG2 cell.
5. ACR suppressed ACAT1 and HMG-CoA reductase expression on mRNA level in HepG2 cell.
Conclusion: This study suggests that ACR has antioxidative and hypolipidemic effect and might be effective in prevention and treatment of dyslipidemia.
Method: We enriched Artemisiae Capillaris, Curcumae Longae and Raphani Semen compound with alcohol. ACR extract is treated to HepG2 cell. Cell groups are devided into 3 groups: normal, control and ACR treated group. We measured polyphenol, flavonoids, DPPH and ABTS radical scavenging activity, ROS, glutathione, GSH peroxidase, GSH reductase, SOD, catalase, free fatty acid, lipid peroxidation and suppression of ACAT1 and HMG-CoA reductase expression on mRNA level.
Results:
1. ACR contained polyphenol and flavonoids and increased GSH significantly in HepG2 cell.
2. ACR increased GPx, GR, and catalase activity significantly in HepG2 cell.
3. ACR increased DPPH and ABTS radical scavenging activity significantly in HepG2 cell and decreased ROS.
4. ACR decreased free fatty acid and MDA significantly in HepG2 cell.
5. ACR suppressed ACAT1 and HMG-CoA reductase expression on mRNA level in HepG2 cell.
Conclusion: This study suggests that ACR has antioxidative and hypolipidemic effect and might be effective in prevention and treatment of dyslipidemia.
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재료 및 방법
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결론
참고문헌
참고문헌 (40)
참고문헌 신청
Statistics Korea. 2015 Cause of death statistics. 2016.
Department of circulatory internal medicine, college of oriental medicine. Korean medicine cardiology and neurology. 4th ed. Seoul:Gunja publisher. 2010:184-189..
Korea national health and nutrition examination survey. 2014 National health statistics. Seajong: Ministry of Health and Welfare. 2015:36-57.
Habukuihakwon. Youngchu-kyungkyosuk. Beijing: Inminwisheng publisher. 1982:161.
Kim HT, Kim YS, Seol IC, Yoo HR. The Effects of an Extract of Artemisiae Capillaris, Curcumae Longae, and Crataegi Fructus (IUS) on Anti-hyperlipidemia and Anti-oxidation in db/db Mouse Model. J. Int. Korean Med. 2016;37(3):467-83.
Korea national health and nutrition examination survey. 2014 National health statistics. Seajong: Ministry of Health and Welfare. 2015:36-57.
Habukuihakwon. Youngchu-kyungkyosuk. Beijing: Inminwisheng publisher. 1982:161.
Kim HT, Kim YS, Seol IC, Yoo HR. The Effects of an Extract of Artemisiae Capillaris, Curcumae Longae, and Crataegi Fructus (IUS) on Anti-hyperlipidemia and Anti-oxidation in db/db Mouse Model. J. Int. Korean Med. 2016;37(3):467-83.
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UCI(KEPA) : I410-ECN-0101-2018-519-001329081