지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.89 No.2
- 발행연도
- 2015.7
- 수록면
- 81 - 86 (6page)
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초록· 키워드
오류제보하기
Purpose: Preoperative neutrophil-to-lymphocyte ratio (NLR) reflects patients’ inflammation status, clinical stage, and survival in various malignancies. However, only a limited amount of information on the clinical importance and prognostic significance of NLR in gastric cancer has been reported. The objective of this study is to assess the prognostic values of preoperative NLR in patients with gastric cancer.
Methods: During the period between August 1, 2005 and December 31, 2011, we collected data from 601 patients among those who had undergone surgery for gastric cancer at the Department of Surgery, Konkuk University Medical Center. We classified the subjects into high NLR (NLR ≥ 1.7) group and low NLR (NLR ＜ 1.7) group.
Results: The gender, age, and American Society of Anesthesiologists (ASA) score did not differ in the two NLR groups. The pathologic features (tumor size, histology, number of examined lymph node, T stage, N stage, and TNM stage) did not differ either, except for tumor location (P = 0.006). Multivariate analysis identified TNM stage, NLR, and age as significant prognostic factors. Gender, tumor size, location, and histology did not show their prognostic significance when we applied the Cox proportional hazard model.
Conclusion: Our study verified that advanced stage, high preoperative NLR (NLR ≥ 1.7), and old age (≥ 70 years) are significant, independent prognostic factor for overall survival in patients with gastric cancer.
Methods: During the period between August 1, 2005 and December 31, 2011, we collected data from 601 patients among those who had undergone surgery for gastric cancer at the Department of Surgery, Konkuk University Medical Center. We classified the subjects into high NLR (NLR ≥ 1.7) group and low NLR (NLR ＜ 1.7) group.
Results: The gender, age, and American Society of Anesthesiologists (ASA) score did not differ in the two NLR groups. The pathologic features (tumor size, histology, number of examined lymph node, T stage, N stage, and TNM stage) did not differ either, except for tumor location (P = 0.006). Multivariate analysis identified TNM stage, NLR, and age as significant prognostic factors. Gender, tumor size, location, and histology did not show their prognostic significance when we applied the Cox proportional hazard model.
Conclusion: Our study verified that advanced stage, high preoperative NLR (NLR ≥ 1.7), and old age (≥ 70 years) are significant, independent prognostic factor for overall survival in patients with gastric cancer.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - 정규원 / 2012 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2009 / Cancer Research and Treatment 44 (1) : 11 ~ 24
[학술지(정기간행물)] - Shin R. / 2012 / Depth of mesorectal extension has prognostic significance in patients with T3 rectal cancer / Dis Colon Rectum 55 : 1220 ~ 1228
[학술지(정기간행물)] - Strauss L. / 2007 / The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck / Clin Cancer Res 13 : 6301 ~ 6311
[학술지(정기간행물)] - Roxburgh CS. / 2009 / Comparison of the prognostic value of inflammation-based pathologic and biochemical criteria in patients undergoing potentially curative resection for colorectal cancer / Ann Surg 249 : 788 ~ 793
[학술지(정기간행물)] - Hwang JE. / 2011 / Prognostic significance of a systemic inflammatory response in patients receiving first-line palliative chemotherapy for recurred or metastatic gastric cancer / BMC Cancer 11 : 489 ~
[학술지(정기간행물)] - Shin R. / 2012 / Depth of mesorectal extension has prognostic significance in patients with T3 rectal cancer / Dis Colon Rectum 55 : 1220 ~ 1228
[학술지(정기간행물)] - Strauss L. / 2007 / The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck / Clin Cancer Res 13 : 6301 ~ 6311
[학술지(정기간행물)] - Roxburgh CS. / 2009 / Comparison of the prognostic value of inflammation-based pathologic and biochemical criteria in patients undergoing potentially curative resection for colorectal cancer / Ann Surg 249 : 788 ~ 793
[학술지(정기간행물)] - Hwang JE. / 2011 / Prognostic significance of a systemic inflammatory response in patients receiving first-line palliative chemotherapy for recurred or metastatic gastric cancer / BMC Cancer 11 : 489 ~
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UCI(KEPA) : I410-ECN-0101-2016-514-001722701