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Neutrophil-to-lymphocyte ratio independently predicts advanced pathological staging and poorer survival outcomes in testicular cancer
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논문 기본 정보

Type
Academic journal
Author
Yu Guang Tan (Singapore General Hospital) Joshua Sia (Singapore General Hospital) Hong Hong Huang (Singapore General Hospital) Weber Kam On Lau (Singapore General Hospital)
Journal
The Korean Urology Association Investigative and Clinical Urology Investigative and Clinical Urology Vol.60 No.3 KCI Accredited Journals
Published
2019.1
Pages
176 - 183 (8page)

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Neutrophil-to-lymphocyte ratio independently predicts advanced pathological staging and poorer survival outcomes in testicular cancer
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Purpose: An elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with adverse outcomes in various malignancies. However, its role in prognosticating testicular cancer (TC) has not been validated. We aim to study the relationship between NLR and TC. Materials and Methods: We retrospectively reviewed 160 patients with histological proven TC from January 2005 to June 2016. Youden's index was used to analyse NLR and a cut-off point of 3.0 was obtained, with statistical receiver operating characteristics of 0.755. Chi-square test, Kaplan-Meier (log rank test) and logistics regression models were used to predict NLR association with survival outcomes. Results: Median age was 34 years old (range, 17–68 years old). There were 102 pure seminomas and 58 non-seminomatous germ cell tumours. Median follow-up period was 8 years (range, 2.5–17 years). NLR ≥3.0 was independently associated with lymph node involvement (p=0.031; odds ratio [OR], 2.91; 95% confidence interval [CI], 1.67–5.83; p=0.038; OR, 4.12; 95% CI, 1.26–6.51) and metastatic disease (p=0.041; OR, 2.48; 95% CI, 1.22–3.98; p=0.043; OR, 2.21; 95% CI, 1.17–3.65) in both seminomatous and non-seminomatous germ cell tumours, translating to a more advanced disease. Moreover, NLR ≥3.0 also predicts poorer cancer specific survival in these patients. Conclusions: NLR can be an inexpensive haematological marker in predicting advanced TC staging and poorer survival outcome. NLR complements the traditional cancer staging by identifying a group of high risk patients who may benefit from multimodal treatment and closer surveillance to achieve long term survival.
#Lymphocytes #Neutrophils #Testicular neoplasms

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Ferlay J / 2013 / Cancer incidence and mortality patterns in Europe : estimates for 40 countries in 2012 / Eur J Cancer 49:1374~1403 google schola National Cancer Institute, Surveillance, Epidemiology, and End Results Program / Cancer stat facts: testicular cancer google schola Znaor A / 2014 / International variations and trends in testicular cancer incidence and mortality / Eur Urol 65:1095~1106 google schola Cancer Research UK / Testicular cancer statistics / Cancer Research UK google schola Mantovani A / 2008 / Cancer-related inflammation / Nature 454:436~444 google schola

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