Oral Concentrated Grape Juice Suppresses Expression of NF-kappa B, TNF-α and iNOS in Experimentally Induced Colorectal Carcinogenesis in Wistar Rats

de Lima Pazine Campanholo, Vanessa Maria; Silva, Roseane Mendes; Silva, Tiago Donizetti; Neto, Ricardo Artigiani; Paiotti, Ana Paula Ribeiro; Ribeiro, Daniel Araki; Forones, Nora Manoukian

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자료유형: 학술저널

저자정보: de Lima Pazine Campanholo, Vanessa Maria (Oncology Group from Gastroenterology Division, Universidade Federal de Sao Paulo) Silva, Roseane Mendes (Oncology Group from Gastroenterology Division, Universidade Federal de Sao Paulo) Silva, Tiago Donizetti (Oncology Group from Gastroenterology Division, Universidade Federal de Sao Paulo) Neto, Ricardo Artigiani (Oncology Group from Gastroenterology Division, Universidade Federal de Sao Paulo) Paiotti, Ana Paula Ribeiro (Oncology Group from Gastroenterology Division, Universidade Federal de Sao Paulo) Ribeiro, Daniel Araki (Oncology Group from Gastroenterology Division, Universidade Federal de Sao Paulo) Forones, Nora Manoukian (Oncology Group from Gastroenterology Division, Universidade Federal de Sao Paulo)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제3호

발행연도: 2015.1

수록면: 947 - 952 (6page)

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The aim of this study was to evaluate the effects of grape juice on colon carcinogenesis induced by azoxymethane (AOM) and expression of NF-kB, iNOS and TNF-${\alpha}$. Methods: Forty male Wistar rats were divided into 7 groups: G1, control; G2, 15 mg/kg AOM; G3, 1% grape juice 2 weeks before AOM; G4, 2% grape juice 2 weeks before AOM; G5, 1% grape juice 4 weeks after AOM; G6, 2% grape juice 4 weeks after AOM; G7, 2% grape juice without AOM. Histological changes and aberrant crypt foci (ACF) were studied, while RNA expression of NF-kB, TNF- and iNOS was evaluated by qPCR. Results: The number of ACF was higher in G2, and G4 presented a smaller number of crypts per focus than G5 (p=0.009) and G6. Small ACF (1-3) were more frequent in G4 compared to G2, G5 and G6 (p=0.009, p=0.009 and p=0.041, respectively). RNA expression of NF-kB was lower in G3 and G4 compared to G2 (p=0.004 and p=0.002, respectively). A positive correlation was observed between TNF-${\alpha}$ and NF-kB gene expression (p=0.002). In conclusion, the administration of 2% grape juice before AOM reduced the crypt multiplicity, attenuating carcinogenesis. Lower expression of NF-kB was observed in animals exposed to grape juice for a longer period of time, regardless of concentration.

#Grape juice #NF-kappa B #TNF- ${alpha}$ #iNOS #carcinogenesis

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