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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제16권 제2호
- 발행연도
- 2015.1
- 수록면
- 60 - 66 (7page)
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초록· 키워드
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α-Viniferin (AVF), a trimer of resveratrol, is known to have an anti-inflammatory effect via inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). It has been reported that up-regulated COX-2 and iNOS are expressed in colon cancer tissues of humans and rodents as well as pre-neoplastic aberrant crypt foci (ACF) of rodents. In this study, chemopreventive effects of AVF were assessed in Caco-2 cells as well as azoxymethane (AOM)-induced colorectal tumorigenesis in mice. Anti-tumor effect of AVF with regards to apoptotic induction was assessed by TUNEL and caspase-3 expression in human colon cancer Caco-2 cells. For development of ACF, AOM was administered with to mice intraperitoneally at a dose of 10 mg/kg once a week for 3 weeks. To induce colitis-related colon cancer, mice were administered a single dose of AOM (10 mg/kg) and 2% dextran sodium sulfate in drinking water. Mice treated with 0.05 and/or 0.1 mg of AVF by gavage showed significantly reduced development of ACF and colorectal tumors. Immunofluorescence detection in Caco-2 cells showed reduced COX-2 and iNOS expression, whereas cleavage of caspase-3 and apoptotic cell numbers increased upon AVF treatment. Immunostaining showed reduced expression levels of COX-2 and iNOS expression along with increased cleaved caspase-3 expression increased upon AVF treatment. These results suggest that AVF has chemopreventive effects on colorectal cancer via anti-inflammatory potential and pro-apoptotic activity.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Aziz MH / 2003 / Cancer chemoprevention by resveratrol : in vitro and in vivo studies and the underlying mechanisms(review) / Int J Oncol 23:17~28
Tang HY / 2006 / Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells / Mol Cancer Ther 5:2034~2042
Joe AK / 2002 / Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines / Clin Cancer Res 8:893~903
Jang M / 1997 / Cancer chemopreventive activity of resveratrol, a natural product derived from grapes / Science 275:218~220
Narayanan BA / 2003 / Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells / Cancer Res 63:972~979
Tang HY / 2006 / Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells / Mol Cancer Ther 5:2034~2042
Joe AK / 2002 / Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines / Clin Cancer Res 8:893~903
Jang M / 1997 / Cancer chemopreventive activity of resveratrol, a natural product derived from grapes / Science 275:218~220
Narayanan BA / 2003 / Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells / Cancer Res 63:972~979
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