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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 39 - 44 (6page)
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Tolfenamic acid (TA) is a traditional non-steroid anti-inflammatory drug (NSAID) and has been broadly used for the treatment of migraines. Nuclear factor kappa B (NF-${\kappa}B$) is a sequence-specific transcription factor and plays a key role in the development and progression of inflammation and cancer. We performed the current study to investigate the underlying mechanisms by which TA suppresses inflammation focusing on NF-${\kappa}B$ pathway in TNF-${\alpha}$ stimulated human normal and cancer cell lines and lipopolysaccharide (LPS)-stimulated mouse macrophages. Different types of human cells (HCT116, HT-29 and HEK293) and mouse macrophages (RAW264.7) were pre-treated with different concentrations of TA and then exposed to inflammatory stimuli such as TNF-${\alpha}$ and LPS. Transcriptional activity of NF-${\kappa}B$, $l{\kappa}B-{\alpha}$-degradation, p65 translocation and mitogen-activated protein kinase (MAPK) activations were measured using luciferase assay and Western blots. Pre-treatment of TA repressed TNF-${\alpha}$- or LPS-stimulated NF-${\kappa}B$ transactivation in a dose-dependent manner. TA treatment reduced degradation of $l{\kappa}B-{\alpha}$ and subsequent translocation of p65 into nucleus. TA significantly down-regulated the phosphorylation of c-Jun N-terminal kinase (JNK). However, TA had no effect on NF-${\kappa}B$ signaling and JNK phosphorylation in HT-29 human colorectal cancer cells. TA possesses anti-inflammatory activities through suppression of JNK/NF-${\kappa}B$ pathway in different types of cells.
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참고문헌 (21)
참고문헌 신청
Abdelrahim, M. / 2006 / Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation / J. Natl. Cancer. Inst 98:855~868
Bergman, M. / 2011 / Inflammation and colorectal cancer: does aspirin affect the interaction between cancer and immune cells? / Inflammation 34:22~28
Corell, T. / 1994 / Pharmacology of tolfenamic acid / Pharmacol. Toxicol 75(2):14~21
Din, F. V. / 2005 / Aspirin-induced nuclear translocation of NFkappaB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency / Br. J. Cancer 92:1137~1143
Dvoriantchikova, G. / 2014 / Tumor necrosis factoralpha mediates activation of NF-kappaB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways / Eur. J. Neurosci 40:3171~3178
Bergman, M. / 2011 / Inflammation and colorectal cancer: does aspirin affect the interaction between cancer and immune cells? / Inflammation 34:22~28
Corell, T. / 1994 / Pharmacology of tolfenamic acid / Pharmacol. Toxicol 75(2):14~21
Din, F. V. / 2005 / Aspirin-induced nuclear translocation of NFkappaB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency / Br. J. Cancer 92:1137~1143
Dvoriantchikova, G. / 2014 / Tumor necrosis factoralpha mediates activation of NF-kappaB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways / Eur. J. Neurosci 40:3171~3178
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