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논문 기본 정보

자료유형
학술저널
저자정보
Chi-Un Pae (The Catholic University of Korea) Changsu Han (Korea University) Won-Myong Bahk (The Catholic University of Korea) Soo-Jung Lee (The Catholic University of Korea) Ashwin A Patkar (Duke University) Prakash S. Masand (Global Medical Education)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제2호
발행연도
2021.1
수록면
233 - 242 (10page)

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Objective: In a number of controlled clinical trials and naturalistic studies, aripiprazole once monthly (AOM) has been found to be effective and safe as acute and maintenance treatment options for schizophrenia. However, such clinical data have been presented in selected patient population (i.e., antipsychotic monotherapy, etc.), in particular, clinical information on switching to AOM from antipsychotic polypharmacy and/or other long acting injectable antipsychotics (LAIs) has been scarce till today. Methods: The study period was from the first switching day to AOM up to 12 months in patients with antipsychotic polypharmacy (APpoly)/LAIs (baseline, month 3, month 6, and month 12). Available demographics and clinical information were retrieved from electronic medical records (EMRs). Available scores of Global Assessment of Functioning (GAF), Clinical Global Impression-Clinical Benefit (CGI-CB), CGI-severity, Visual Analog Scale on Satisfaction-Patient/Health Professional (VAS-P/HP), and the Positive and Negative Syndrome Scale-Insigh (PANSS-I) scores were also taken from EMR. Proportional change of functional impairment before and after AOM was also captured. Results: Data of 18 patients were available. Most commonly used combined APs before AOM were aripiprazole, blonanserin, quetiapine, and risperidone. At least 2 APs (n = 2.4) were combined before AOM. Scores of GAF (10.7% increase), CGI-CB (46.2% decrease), VAS-P (47.8% increase), VAS-HP (40.8% increase), and PANSS-I (27.9% increase) (all p = 0.001) were significantly improved from baseline to month 12, respectively. Approximately 59% of patients improved individual functioning with different level (i.e., employment, back to school, etc.) after AOM treatment at month 12. Conclusion: The present study have clearly shown the clinical benefit and utility of switching to AOM for treatment of patients with APpoly/LAIs in routine practice. Subsequent, adequately-powered, well-controlled clinical trials may be necessary to confirm our findings in near future.
#Aripiprazole once monthly #Long-acting injectable antipsychotics #Polypharmacy #Clinical utility #Schizophrenia #Benefit.

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참고문헌 (42)

참고문헌 신청
Otsuka Pharmaceutical Co., Ltd / 2013 / The manual of Abilify Maintena Kit / Otsuka Pharmaceutical Co., Ltd google schola Pae CU / 2017 / Comparison between long-acting injectable aripiprazole versus paliperidone palmitate in the treatment of schizophrenia : systematic review and indirect treatment comparison / Int Clin Psychopharmacol 32:235~248 google schola Park MH / 2011 / Aripiprazole treatment for patients with schizophrenia : from acute treatment to maintenance treatment / Expert Rev Neurother 11:1541~1552 google schola Fleischhacker WW / 2014 / Aripiprazole once-monthly for treatment of schizophrenia : double-blind, randomised, non-inferiority study / Br J Psychiatry 205:135~144 google schola Kane JM / 2012 / Aripiprazole intramuscular depot as maintenance treatment in patients with schizophrenia : a 52-week, multicenter, randomized, double-blind, placebo-controlled study / J Clin Psychiatry 73:617~624 google schola

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