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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 159 - 164 (6page)
이용수
초록· 키워드
오류제보하기
NF-κB transcription factors are key regulators of immune and stress responses, apoptosis, and differentiation. Human cytomegalovirus (HCMV) activates or represses NF-κB signaling at different times during infection. An initial increase in NF-κB activity occurs within a few hours of infection. The virus appears to adapt to this change since initial viral gene expression is promoted by the elevated NF-κB activity. Because NF-κB upregulates innate immune responses and inflammation, it has also been suggested that HCMV needs to downregulate NF-κB signaling. Recent studies have shown that HCMV has various mechanisms that inhibit NF-κB signaling. HCMV reduces cell surface expression of tumor necrosis factor receptor 1 (TNFR1) and blocks the DNA binding activity of NF-κB. Furthermore, some HCMV tegument proteins antagonize NF-κB activation by targeting the key components of NF-κB signaling at late stages of infection. In this review, we summarize the recent findings on the relationship between HCMV and NF-κB signaling, focusing, in particular, on the viral mechanisms by which the NF-κB signaling pathway is inhibited.
목차
INTRODUCTION
CLOSING REMARKS
REFERENCES
참고문헌 (30)
참고문헌 신청
[단행본] - Mocarski ES / 2007 / Fields virology / Lippincott Williams & Wilkins
[학술지(정기간행물)] - Stenberg RM / 1996 / The human cytomegalovirus major immediate-early gene / Intervirology 39 : 343 ~ 349
[학술지(정기간행물)] - Oeckinghaus A / 2011 / Crosstalk in NF-kappaB signaling pathways / Nat Immunol 12 : 695 ~ 708
[학술지(정기간행물)] - Kowalik TF / 1993 / Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection / Proc Natl Acad Sci U S A 90 : 1107 ~ 1111
[학술지(정기간행물)] - Sambucetti LC / 1989 / NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation / EMBO J 8 : 4251 ~ 4258
[학술지(정기간행물)] - Stenberg RM / 1996 / The human cytomegalovirus major immediate-early gene / Intervirology 39 : 343 ~ 349
[학술지(정기간행물)] - Oeckinghaus A / 2011 / Crosstalk in NF-kappaB signaling pathways / Nat Immunol 12 : 695 ~ 708
[학술지(정기간행물)] - Kowalik TF / 1993 / Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection / Proc Natl Acad Sci U S A 90 : 1107 ~ 1111
[학술지(정기간행물)] - Sambucetti LC / 1989 / NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation / EMBO J 8 : 4251 ~ 4258
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