Predictive Role of Neutrophil Gelatinase-Associated Lipocalin in Early Diagnosis of Platin-Induced Renal Injury

Seker, Mehmet Metin; Deveci, Koksal; Seker, Ayse; Sancakdar, Enver; Yilmaz, Ali; Turesin, A. Kerim; Kacan, Turgut; Babacan, Nalan A.

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저자정보: Seker, Mehmet Metin (Medical Oncology Department, Faculty of Medicine, Cumhuriyet University) Deveci, Koksal (Biochemistry Department, Faculty of Medicine, Cumhuriyet University) Seker, Ayse (Public Health Directorate) Sancakdar, Enver (Biochemistry Department, Faculty of Medicine, Cumhuriyet University) Yilmaz, Ali (Internal Medicine Department, Faculty of Medicine, Cumhuriyet University) Turesin, A. Kerim (Internal Medicine Department, Faculty of Medicine, Cumhuriyet University) Kacan, Turgut (Medical Oncology Department, Faculty of Medicine, Cumhuriyet University) Babacan, Nalan A. (Medical Oncology Department, Faculty of Medicine, Cumhuriyet University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제2호

발행연도: 2015.1

수록면: 407 - 410 (4page)

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Background: Acute kidney injury is an important issue in chemotherapy receiving patients an neutrophil gelatinase-associated lipocalin has been proposed as a novel marker. We here aimed to assess the role of urinary levels for assessment after platin exposure. Materials and Methods: Patients who had treated with cisplatin or carboplatin or oxaliplatin containg regimens were included in this study. Baseline and postchemotherapy serum urea, creatinine, urine neutrophil gelatinase-associated lipocalin and urine creatinine levels were determined. To avoid the effects of hydration during chemotherapy infusion the urinary neutrophil gelatinase-associated lipocalin/urine creatinine ratio was used to determine acute kidney injury. Results: Of a total of 42 patients receiving platin compounds,14 (33.3%) received cisplatin containing regimens, 14 (33.3%) received carboplatin and 14 (33.3%) oxaliplatin. The median age was 60 (37-76) years. Nineteen of the patients (45.2%) had lung cancer, 12 (28.6%) colorectal cancer and 11 (26.2%) others. The median pre and post chemotherapy urine neutrophil gelatinase-associated lipocalin/urine creatinin ratio was 15.6 ng/mg and 35.8 ng/mg (p=0.041) in the cisplatin group, 32.5 ng/mg and 86.3 ng/mg (p=0.004) in the carboplatin group and 40.9 ng/mg and 62.3 ng/mg (p=0.243) in the oxaliplatin group. Conclusions: Nephrotoxicity is a serious side effect of chemotherapeutic agentslike cisplatin and carbopaltin, but only to a lower extent oxaliplatin. All platin compounds must be used carefully and urine neutrophil gelatinase-associated lipocalin measurement seems to be promising in detecting acute kidney injury earlier than with creatinine.

#Neutrophil gelatinase-associated lipocalin #cancer #platin chemotherapy #nephrotoxicity

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