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논문 기본 정보

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저자정보
Asakage Ayu (INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Université de Paris Cité, Paris, France) Ishihara Shiro (Department of Cardiovascular Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan) Boutin Louis (INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Université de Paris Cité, Paris, FranceDepartment of Anesthesiology, Critical Care and Burn Unit, University Hospitals) Dépret François (INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Université de Paris Cité, Paris, FranceDepartment of Anesthesiology, Critical Care and Burn Unit, University Hospitals) Sugaya Takeshi (Department of Nephrology and Hypertension, St. Marianna University School of Medicine, Kanagawa, Japan) Sato Naoki (Department of Cardiovascular Medicine, Kawaguchi Cardiovascular and Respiratory Hospital, Kawaguchi, Japan) Gayat Etienne (INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Université de Paris Cité, Paris, FranceDepartment of Anesthesiology, Critical Care and Burn Unit, University Hospitals) Mebazaa Alexandre (INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Université de Paris Cité, Paris, FranceDepartment of Anesthesiology, Critical Care and Burn Unit, University Hospitals) Deniau Benjamin (INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Université de Paris Cité, Paris, FranceDepartment of Anesthesiology, Critical Care and Burn Unit, University Hospitals)
저널정보
대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제44권 제2호
발행연도
2024.3
수록면
144 - 154 (11page)
DOI
10.3343/alm.2023.0083

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Background: Acute kidney injury (AKI) is a common condition in severely ill patients asso- ciated with poor outcomes. We assessed the associations between urinary neutrophil ge- latinase-associated lipocalin (uNGAL), urinary liver-type fatty acid-binding protein (uLFABP), and urinary cystatin C (uCysC) concentrations and patient outcomes. Methods: We assessed the predictive performances of uNGAL, uLFABP, and uCysC mea- sured in the early phase of intensive care unit (ICU) management and at discharge from the ICU in severely ill patients for short- and long-term outcomes. The primary outcome was the occurrence of AKI during ICU stay; secondary outcomes were 28-day and 1-yr all- cause mortality. Results: In total, 1,759 patients were admitted to the ICU, and 728 (41.4%) developed AKI. Median (interquartile range, IQR) uNGAL, uLFABP, and uCysC concentrations on ad- mission were 147.6 (39.9–827.7) ng/mL, 32.4 (10.5–96.0) ng/mL, and 0.33 (0.12–2.05) mg/L, respectively. Biomarker concentrations on admission were higher in patients who developed AKI and associated with AKI severity. Three hundred fifty-six (20.3%) and 647 (37.9%) patients had died by 28 days and 1-yr, respectively. Urinary biomarker concentra- tions at ICU discharge were higher in non-survivors than in survivors. The areas under the ROC curve (95% confidence interval) of uLFABP for the prediction of AKI, 28-day mortality, and 1-yr mortality (0.70 [0.67–0.72], 0.63 [0.59–0.66], and 0.57 [0.51–0.63], respec- tively) were inferior to those of the other biomarkers. Conclusions: uNGAL, uLFABP, and uCysC concentrations on admission were associated with poor outcomes. However, their predictive performance, individually and in combina- tion, was limited. Further studies are required to confirm our results.
#Acute kidney injury #Cystatin C #Intensive care unit #Liver-type fatty acid-binding protein #Mortality #Neutrophil gelatinase-associated lipocalin

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