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논문 기본 정보
- 자료유형
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- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제1호
- 발행연도
- 2020.1
- 수록면
- 1 - 10 (10page)
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Autophagy is a highly conserved intracellular degradation and energyrecycling mechanism that contributes to the maintenance of cellular homeostasis. Extensive researches over the past decades have defined the role of autophagy innate immune cells. In this review, we describe the current state of knowledge regarding the role of autophagy in neutrophil biology and a picture of molecular mechanism underlying autophagy in neutrophils. Neutrophils are professional phagocytes that comprise the first line of defense against pathogen. Autophagy machineries are highly conserved in neutrophils. Autophagy is not only involved in generalized function of neutrophils such as differentiation in bone marrow but also plays crucial role effector functions of neutrophils such as granule formation, degranulation, neutrophil extracellular traps release, cytokine production, bactericidal activity and controlling inflammation. This review outlines the current understanding of autophagy in neutrophils and provides insight towards identification of novel therapeutics targeting autophagy in neutrophils
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참고문헌 (107)
참고문헌 신청
Nathan C / 2006 / Neutrophils and immunity : challenges and opportunities / Nat Rev Immunol 6:173~182
Furze RC / 2008 / Neutrophil mobilization and clearance in the bone marrow / Immunology 125:281~288
Hampton MB / 1998 / Inside the neutrophil phagosome : oxidants, myeloperoxidase, and bacterial killing / Blood 92:3007~3017
Segal AW / 2005 / How neutrophils kill microbes / Annu Rev Immunol 23:197~223
Brinkmann V / 2004 / Neutrophil extracellular traps kill bacteria / Science 303:1532~1535
Furze RC / 2008 / Neutrophil mobilization and clearance in the bone marrow / Immunology 125:281~288
Hampton MB / 1998 / Inside the neutrophil phagosome : oxidants, myeloperoxidase, and bacterial killing / Blood 92:3007~3017
Segal AW / 2005 / How neutrophils kill microbes / Annu Rev Immunol 23:197~223
Brinkmann V / 2004 / Neutrophil extracellular traps kill bacteria / Science 303:1532~1535
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