개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 425 - 430 (6page)
이용수
초록· 키워드
오류제보하기
Background: Urinary tract infection (UTI) is the most common bacterial infection in infants. Renal parenchymal involvement is an important prognostic factor; however, early detection of parenchymal involvement in UTI may be difficult during infancy. This study aimed to assess whether a recently established biomarker of UTI, neutrophil gelatinase-associated lipocalin (NGAL), can serve as a useful marker for the detection of cortical defects (CD) and to determine the appropriate diagnostic cut-off value of NGAL in infants with febrile UTI. Methods: Infants hospitalized for febrile UTI were divided into two groups according to the presence of cortical defects on dimercaptosuccinic acid (DMSA) scintigraphy. Among 64 enrolled infants, 43 (67%) had CD (UTI-CD) and 21 (33%) had no CD (UTI-ND). The white blood cell count, C-reactive protein, and plasma NGAL (pNGAL) levels were determined before antibiotic therapy and compared between the two groups. Results: pNGAL level was significantly higher in the UTI-CD group than in the UTI-ND group (340 μg/L vs 214 μg/L, P=0.002). Multivariate analysis showed that pNGAL level was the only independent predictor of CD (odds ratio 2.759, P=0.039). In the ROC curve analysis, pNGAL showed the highest area under the curve (0.745; 95% confidence interval, 0.561–0.821; P=0.014). The appropriate cut-off value of pNGAL was 267 μg/L (sensitivity, 72.1%; specificity, 71.4%). Conclusions: pNGAL was found to be a useful marker for early prediction of renal parenchymal involvement in infants with febrile UTI.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Jakobsson B / 1999 / Minimum incidence and diagnostic rate of first urinary tract infection / Pediatrics 104:222~226
Peters CA / 2010 / Summary of the AUA guideline on management of primary vesicoureteral reflux in children / J Urol 184:1134~1144
Young Seo Park / 2012 / Renal scar formation after urinary tract infection in children / Korean Journal of Pediatrics 55(10):367~370
Jaye DL / 1997 / Clinical applications of C-reactive protein in pediatrics / Pediatr Infect Dis J 16:735~746
de Man P / 1991 / Bacterial attachment, inflammation and renal scarring in urinary tract infection / Wien Med Wochenschr 141:537~540
Peters CA / 2010 / Summary of the AUA guideline on management of primary vesicoureteral reflux in children / J Urol 184:1134~1144
Young Seo Park / 2012 / Renal scar formation after urinary tract infection in children / Korean Journal of Pediatrics 55(10):367~370
Jaye DL / 1997 / Clinical applications of C-reactive protein in pediatrics / Pediatr Infect Dis J 16:735~746
de Man P / 1991 / Bacterial attachment, inflammation and renal scarring in urinary tract infection / Wien Med Wochenschr 141:537~540
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Clinical Efficacy of a Top-down Approach for Children with a First Febrile Urinary Tract Infection
Childhood Kidney Diseases
2017 .01
-
Clinical Characteristics of Febrile UTI First Developed Over 5 Years of Age
Childhood Kidney Diseases
2017 .01
-
Plasma Neutrophil Gelatinase-associated Lipocalin and Leukocyte Differential Count in Children with Febrile Urinary Tract Infection
Childhood Kidney Diseases
2021 .12
-
Clinical Experiences with Febrile Infants, Younger than Three Months, with Urinary Tract Infection in a Single Center for Four Years : Incidence, Pathogens and Viral Co-infections
Childhood Kidney Diseases
2017 .01
-
A clinical prediction tool to predict urinary tract infection in pediatric febrile patients younger than 2 years old: a retrospective analysis of a fever registry
Clinical and Experimental Emergency Medicine
2021 .12
-
Differentiation between Viral and Urinary Tract Infections Using the Modified Rochester Criteria In Febrile Infants Younger than three Months
Childhood Kidney Diseases
2015 .01
-
Delta neutrophil index as a predictor of vesicoureteral reflux in children with febrile urinary tract infection
Childhood Kidney Diseases
2022 .06
-
Predictive value of C-reactive protein for the diagnosis of meningitis in febrile infants under 3 months of age in the emergency department
Journal of Yeungnam Medical Science
2020 .01
-
Associations of Plasma Neutrophil Gelatinase-associated Lipocalin, Anemia, and Renal Scarring in Children with Febrile Urinary Tract Infections
Journal of Korean Medical Science
2020 .01
-
Diagnostic accuracy of urinary biomarkers in infants younger than 3 months with urinary tract infection
Korean journal of pediatrics
2018 .01
-
Association of Renal and Bladder Ultrasonography Findings with Urinary Tract Infection Recurrence, High- Grade Vesicoureteral Reflux, and Renal Scarring
Childhood Kidney Diseases
2015 .01
-
Plasma Neutrophil Gelatinase-Associated Lipocalin as a Marker of Tubular Damage in Diabetic Nephropathy
Annals of Laboratory Medicine
2018 .01
-
Prediction of Cortical Defect Using C-Reactive Protein and Urine Sodium to Potassium Ratio in Infants with Febrile Urinary Tract Infection
Yonsei Medical Journal
2016 .01
-
Predictors of High-grade Vesicoureteral Reflux in Children with Febrile Urinary Tract Infections
Childhood Kidney Diseases
2017 .01
-
Ureteral Stent Induced Urinary Tract Infection and Microbial Inconsistency Between Bladder and Renal Pelvis
Urogenital Tract Infection
2021 .12
-
호중구 감소성 발열을 보이는 소아 암 환자에서의 요로감염에 대한 연구
Journal of Yeungnam Medical Science
2016 .12
-
Relationship between Obesity and UTI in Children Under 2 Years of Age Admitted with Fever
Childhood Kidney Diseases
2018 .01
-
호중구 감소성 발열을 보이는 소아 암 환자에서의 요로감염에 대한 연구
영남의대학술지
2016 .01
-
Clinical Characteristics and Outcomes of the First Episode of Urinary Tract Infection in Neonates and Infants Younger than 2 Months of Age
Childhood Kidney Diseases
2017 .01
-
Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection
Korean journal of pediatrics
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0