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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 425 - 430 (6page)
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초록· 키워드
오류제보하기
Background: Urinary tract infection (UTI) is the most common bacterial infection in infants. Renal parenchymal involvement is an important prognostic factor; however, early detection of parenchymal involvement in UTI may be difficult during infancy. This study aimed to assess whether a recently established biomarker of UTI, neutrophil gelatinase-associated lipocalin (NGAL), can serve as a useful marker for the detection of cortical defects (CD) and to determine the appropriate diagnostic cut-off value of NGAL in infants with febrile UTI. Methods: Infants hospitalized for febrile UTI were divided into two groups according to the presence of cortical defects on dimercaptosuccinic acid (DMSA) scintigraphy. Among 64 enrolled infants, 43 (67%) had CD (UTI-CD) and 21 (33%) had no CD (UTI-ND). The white blood cell count, C-reactive protein, and plasma NGAL (pNGAL) levels were determined before antibiotic therapy and compared between the two groups. Results: pNGAL level was significantly higher in the UTI-CD group than in the UTI-ND group (340 μg/L vs 214 μg/L, P=0.002). Multivariate analysis showed that pNGAL level was the only independent predictor of CD (odds ratio 2.759, P=0.039). In the ROC curve analysis, pNGAL showed the highest area under the curve (0.745; 95% confidence interval, 0.561–0.821; P=0.014). The appropriate cut-off value of pNGAL was 267 μg/L (sensitivity, 72.1%; specificity, 71.4%). Conclusions: pNGAL was found to be a useful marker for early prediction of renal parenchymal involvement in infants with febrile UTI.
목차
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참고문헌 (27)
참고문헌 신청
Jakobsson B / 1999 / Minimum incidence and diagnostic rate of first urinary tract infection / Pediatrics 104:222~226
Peters CA / 2010 / Summary of the AUA guideline on management of primary vesicoureteral reflux in children / J Urol 184:1134~1144
Young Seo Park / 2012 / Renal scar formation after urinary tract infection in children / Korean Journal of Pediatrics 55(10):367~370
Jaye DL / 1997 / Clinical applications of C-reactive protein in pediatrics / Pediatr Infect Dis J 16:735~746
de Man P / 1991 / Bacterial attachment, inflammation and renal scarring in urinary tract infection / Wien Med Wochenschr 141:537~540
Peters CA / 2010 / Summary of the AUA guideline on management of primary vesicoureteral reflux in children / J Urol 184:1134~1144
Young Seo Park / 2012 / Renal scar formation after urinary tract infection in children / Korean Journal of Pediatrics 55(10):367~370
Jaye DL / 1997 / Clinical applications of C-reactive protein in pediatrics / Pediatr Infect Dis J 16:735~746
de Man P / 1991 / Bacterial attachment, inflammation and renal scarring in urinary tract infection / Wien Med Wochenschr 141:537~540
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