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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 109 - 114 (6page)
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초록· 키워드
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Liquiritigenin (LQ) is a flavonoid that can be isolated from Glycyrrhiza radix. It is frequently used as a tranditional oriental medicine herbal treatment for swelling and injury and for detoxification. However, the effects of LQ on cognitive function have not been fully explored. In this study, we evaluated the memory-enhancing effects of LQ and the underlying mechanisms with a focus on the N-methyl-D-aspartic acid receptor (NMDAR) in mice. Learning and memory ability were evaluated with the Y-maze and passive avoidance tests following administration of LQ. In addition, the expression of NMDAR subunits 1, 2A, and 2B; postsynaptic density-95 (PSD-95); phosphorylation of $Ca^{2+}$/calmodulin-dependent protein kinase II (CaMKII); phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2); and phosphorylation of cAMP response element binding (CREB) proteins were examined by Western blot. In vivo, we found that treatment with LQ significantly improved memory performance in both behavioral tests. In vitro, LQ significantly increased NMDARs in the hippocampus. Furthermore, LQ significantly increased PSD-95 expression as well as CaMKII, ERK, and CREB phosphorylation in the hippocampus. Taken together, our results suggest that LQ has cognition enhancing activities and that these effects are mediated, in part, by activation of the NMDAR and CREB signaling pathways.
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참고문헌 (43)
참고문헌 신청
Aamodt, S. M. / 1999 / The role of neural activity in synaptic development and its implications for adult brain function / Adv. Neurol. 79:133~144
Alberini, C. M. / 2009 / Transcription factors in long-term memory and synaptic plasticity / Physiol. Rev. 89:121~145
Armano, S. / 2000 / Long-term potentiation of intrinsic excitability at the mossy fiber-granule cell synapse of rat cerebellum / J. Neurosci. 20:5208~5216
Barki-Harrington, L. / 2009 / Tyrosine phosphorylation of the 2B subunit of the NMDA receptor is necessary for taste memory formation / J. Neurosci. 29:9219~9226
Danysz, W. / 2012 / Alzheimer's disease, ${\beta}$ -amyloid, glutamate, NMDA receptors and memantine-searching for the connections / Br. J. Pharmacol. 167:324~352
Alberini, C. M. / 2009 / Transcription factors in long-term memory and synaptic plasticity / Physiol. Rev. 89:121~145
Armano, S. / 2000 / Long-term potentiation of intrinsic excitability at the mossy fiber-granule cell synapse of rat cerebellum / J. Neurosci. 20:5208~5216
Barki-Harrington, L. / 2009 / Tyrosine phosphorylation of the 2B subunit of the NMDA receptor is necessary for taste memory formation / J. Neurosci. 29:9219~9226
Danysz, W. / 2012 / Alzheimer's disease,
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