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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 555 - 564 (10page)
이용수
초록· 키워드
오류제보하기
Background: Ginsenosides of Panax ginseng are used to enhance skin health and beauty. The present study aimed to investigate the potential use of ginsenoside Rf (Rf) from Panax ginseng as a new anti-pigmentation agent.
Methods: The anti-melanogenic effects of Rf were explored. The transcriptional activity of the cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the expression levels of tyrosinase, microphthalmia-associated transcription factor (MITF), and tyrosinase-related proteins (Tyrps) were evaluated in melanocytes and UV-irradiated ex vivo human skin.
Results: Rf significantly inhibited Forskolin (FSK) or UV-stimulated melanogenesis. Consistently, cellular tyrosinase activity and levels of MITF, tyrosinase, and Tyrps were downregulated. Furthermore, Rf suppressed MITF promoter activity, which was stimulated by FSK or CREB-regulated transcription coactivator 3 (CRTC3) overexpression. Increased CREB phosphorylation and protein kinase A (PKA) activity induced by FSK were also mitigated in the presence of Rf.
Conclusion: Rf can be used as a reliable anti-pigmentation agent, which has a scientifically confirmed and reproducible action mechanism, via inhibition of CREB/MITF pathway.
Methods: The anti-melanogenic effects of Rf were explored. The transcriptional activity of the cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the expression levels of tyrosinase, microphthalmia-associated transcription factor (MITF), and tyrosinase-related proteins (Tyrps) were evaluated in melanocytes and UV-irradiated ex vivo human skin.
Results: Rf significantly inhibited Forskolin (FSK) or UV-stimulated melanogenesis. Consistently, cellular tyrosinase activity and levels of MITF, tyrosinase, and Tyrps were downregulated. Furthermore, Rf suppressed MITF promoter activity, which was stimulated by FSK or CREB-regulated transcription coactivator 3 (CRTC3) overexpression. Increased CREB phosphorylation and protein kinase A (PKA) activity induced by FSK were also mitigated in the presence of Rf.
Conclusion: Rf can be used as a reliable anti-pigmentation agent, which has a scientifically confirmed and reproducible action mechanism, via inhibition of CREB/MITF pathway.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (52)
참고문헌 신청
Briganti S / 2003 / Chemical and instrumental approaches to treat hyperpigmentation / Pigment Cell Research 16:101~110
Engasser PG / 1981 / Cosmetics and dermatology : bleaching creams / Journal of the American Academy of Dermatology 5:143~147
Yamaguchi Y / 2009 / Physiological factors that regulate skin pigmentation / Biofactors 35:193~199
Slominski A / 2004 / Melanin pigmentation in mammalian skin and its hormonal regulation / Physiological Reviews 84:1155~1228
Bang S / 2017 / Novel regulation of melanogenesis by adiponectin via the AMPK/CRTC pathway / Pigment Cell Melanoma Res 30:553~557
Engasser PG / 1981 / Cosmetics and dermatology : bleaching creams / Journal of the American Academy of Dermatology 5:143~147
Yamaguchi Y / 2009 / Physiological factors that regulate skin pigmentation / Biofactors 35:193~199
Slominski A / 2004 / Melanin pigmentation in mammalian skin and its hormonal regulation / Physiological Reviews 84:1155~1228
Bang S / 2017 / Novel regulation of melanogenesis by adiponectin via the AMPK/CRTC pathway / Pigment Cell Melanoma Res 30:553~557
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