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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 35 - 40 (6page)
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초록· 키워드
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Objective: The role of BDNF (brain-derived neurotrophic factor), CREB (cAMP response element binding) and VGF neuropeptide has been proved in antidepressant activity of long term saffron administration in the rat hippocampus. In this study we evaluated the role of these proteins in antidepressant activity of saffron in long term administration in the rat cerebellum. Methods: Saffron aqueous extract (40 and 80 mg/kg/ day) and imipramine (10 mg/kg/day) were administered intraperitoneally for 21 days to rats. At the end of experiment, animals were sacrificed and cerebellums were separated. The protein levels of BDNF, VGF, CREB and P- CREB in the rat cerebellum were evaluated using western blot analysis. Results: Saffron aqueous extract (80mg/kg/day) caused significant increase in protein level of P-CREB in long term treatment in the rat cerebellum. The increases in the protein levels of VGF, CREB and BDNF were not significant. Conclusion: In summary, our results showed that antidepressant effect of saffron in rat cerebellum might be due to the enhanced phosphorylation of CREB.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Berton O / 2006 / New approaches to antidepressant drug discovery: beyond monoamines / Nature Rev Neurosci 7(2):137~151
Haenisch B / 2011 / Depression and antidepressants: insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters / Pharmacol Ther 129(3):352~368
Penga J / 2011 / Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: A voxel-based morphometry study / Eur J Radiol 80:395~399
Zeng L / 2012 / Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression / Plos One 7(8):e44248
Yulug B / 2009 / Brain-derived neurotrophic factor, stress and depression: a minireview / Brain Res Bull 78(6):267~269
Haenisch B / 2011 / Depression and antidepressants: insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters / Pharmacol Ther 129(3):352~368
Penga J / 2011 / Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: A voxel-based morphometry study / Eur J Radiol 80:395~399
Zeng L / 2012 / Antidepressant Treatment Normalizes White Matter Volume in Patients with Major Depression / Plos One 7(8):e44248
Yulug B / 2009 / Brain-derived neurotrophic factor, stress and depression: a minireview / Brain Res Bull 78(6):267~269
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