지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 74 - 80 (7page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaThe aims of the present study were to explore the behavioural effects and to understand the possible mode of action of Bacopa monnieri extract (BME) on chronic unpredictable stress (CUS) induced depressive model and the biochemical alterations such as brain derived neurotrophic factor (BDNF), Akt, cyclic-AMP response element binding (CREB) protein level in the hippocampus of rats.
MethodsaaWe examined the effects of chronic administration of BME on CUS exposed rats for 28 days. Behavioural changes were assessed by sucrose consumption and open field test to assess the effect of BME on CUS-induced depression. The mechanisms underlying antidepressant like action of BME was further evaluated by measuring levels of BDNF, Akt, and CREB in the hippocampus of rat brain and compared with the standard tricyclic antidepressant drug imipramine (20 mg/kg body weight).
ResultsaaExposure to CUS for 28 days produced depression-like behavior in rats, as indicated by significant decreases in sucrose consumption, locomotor activity including decreased BDNF, Akt and CREB levels in the hippocampus. Daily administration of BME at a dose of (80 mg/kg body weight) significantly reverses the behavioral alteration and restored the normal level of BDNF, total and phospho-Akt, total and phospho CREB in the hippocampus of CUS induced rats as compared to vehicle treated control rats.
ConclusionaaThese findings suggest that BME ameliorates CUS induced behavioural depression in rats and that can be used as a potent therapeutic agent in treating depressive like behavior.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Shelton RC / 2007 / The molecular neurobiology of depression / Psychiatr Clin North Am 30:1~11
Kessler RC / 2005 / Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication / Arch Gen Psychiatry 62:617~627
Ritabrata Banerjee / 2014 / Chronic Administration of Bacopa Monniera Increases BDNF Protein and mRNA Expressions: A Study in Chronic Unpredictable Stress Induced Animal Model of Depression / PSYCHIATRY INVESTIGATION 11(3):297~306
Mao QQ / 2010 / Effects of SYJN, a Chinese herbal formula, on chronic unpredictable stress-induced changes in behavior and brain BDNF in rats / J Ethnopharmacol 128:336~341
Hazra S / 2013 / Bacopa monniera treatment reverses chronic unpredictable stress induced depressive like behavior by increasing expression of neurotrophins in rat brain / RJPBCS 4:775~786
Kessler RC / 2005 / Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication / Arch Gen Psychiatry 62:617~627
Ritabrata Banerjee / 2014 / Chronic Administration of Bacopa Monniera Increases BDNF Protein and mRNA Expressions: A Study in Chronic Unpredictable Stress Induced Animal Model of Depression / PSYCHIATRY INVESTIGATION 11(3):297~306
Mao QQ / 2010 / Effects of SYJN, a Chinese herbal formula, on chronic unpredictable stress-induced changes in behavior and brain BDNF in rats / J Ethnopharmacol 128:336~341
Hazra S / 2013 / Bacopa monniera treatment reverses chronic unpredictable stress induced depressive like behavior by increasing expression of neurotrophins in rat brain / RJPBCS 4:775~786
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