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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제2호
- 발행연도
- 2018.3
- 수록면
- 155 - 162 (8page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.2.155
이용수
이 논문의 연구 히스토리 (2)
2018
The antidepressant action of 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid is mediated by phosphorylation of histone deacetylase 5
박민협
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최미연
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김용석
외 1명
The Korean Journal of Physiology & Pharmacology
2018.03
학술저널
3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid 의 histone deacetylase 5 인산화에 의한 항우울효과에 대한 연구
박민협
의생명과학과
2018.01
학위논문
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초록· 키워드
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3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a competitive N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant- like effects in animal models of depression. However, the molecular mechanisms underlying these behavioral actions remain unknown. Here, we demonstrate that CPP rapidly stimulates histone deacetylase (HDAC) 5 phosphorylation and nuclear export in rat hippocampal neurons. These effects are accompanied by calcium/calmodulin kinase II (CaMKII) and protein kinase D (PKD) phosphorylation. Behavioral experiments revealed that viral-mediated hippocampal knockdown of HDAC5 blocked the antidepressant effects of CPP in stressed animals. Taken together, our results imply that CPP acts via HDAC5 and suggest that HDAC5 is a common regulator contributing to the antidepressant actions of NMDA receptor antagonists such as CPP.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Duman RS / 2012 / Synaptic dysfunction in depression: potential therapeutic targets / Science 338:68~72
Savitz J / 2009 / Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide / Neurosci Biobehav Rev 33:699~771
Kang HJ / 2012 / Decreased expression of synapse-related genes and loss of synapses in major depressive disorder / Nat Med 18:1413~1417
MacQueen GM / 2008 / Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder / Biol Psychiatry 64:880~883
Vyas A / 2002 / Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons / J Neurosci 22:6810~6818
Savitz J / 2009 / Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide / Neurosci Biobehav Rev 33:699~771
Kang HJ / 2012 / Decreased expression of synapse-related genes and loss of synapses in major depressive disorder / Nat Med 18:1413~1417
MacQueen GM / 2008 / Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder / Biol Psychiatry 64:880~883
Vyas A / 2002 / Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons / J Neurosci 22:6810~6818
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