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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 221 - 229 (9page)
- DOI
- 10.20307/nps.2020.26.3.221
이용수
이 논문의 연구 히스토리 (5)
2016
Inhibitory Effect of 1,3-Dipalmitoyl-2-Oleoylglycerol Derived from Rice Bran oil on Ischemia-Induced Neurotoxicity
Ji Yeon Jang
,
Yeon Hee Seong
한국약용작물학회 학술대회논문집
2016.10
학술대회자료
Inhibitory Effect of Rice Bran Oil on β-Amyloid Protein (25-35)-Induced Memory Impairment and Neurotoxicity
Ji Yeon Jang
,
Yeon Hee Seong
한국약용작물학회 학술대회논문집
2016.10
학술대회자료
Protective Effect of Rice Bran Oil on Ischemia-Induced Neurotoxicity
Ji Yeon Jang
,
Yeon Hee Seong
한국약용작물학회 학술대회논문집
2016.10
학술대회자료
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초록· 키워드
오류제보하기
This study was undertaken to investigate the protective effect of rice bran oil (RBO) on amyloid β protein (Aβ) (25-35)-induced memory impairment and brain damage in an ICR mouse model. Memory impairment was produced by intracerebroventricular microinjection of 15 nmol Aβ (25-35) and assessed using the passive avoidance test. Treatment with RBO at 0.1, 0.5, or 1 mL/kg (p.o. daily for 8 days) protected against Aβ (25-35)-induced memory impairment. Furthermore, Aβ (25-35)-induced decreases in glutathione and increases in lipid peroxidation and cholinesterase activity in brain tissue were inhibited by RBO, and Aβ (25-35)- induced increases of phosphorylated mitogen-activated protein kinases (MAPKs) and inflammatory factors, and changes in the levels of apoptosis-related proteins were significantly inhibited by RBO. Furthermore, Aβ (25-35) suppressed the PI3K/Akt pathway and the phosphorylation of CREB, but increased phosphorylation of tau (p-tau) in mice brain; these effects were significantly inhibited by administration of RBO. These results suggest that RBO inhibits Aβ (25-35)-induced memory impairment by inducing anti-apoptotic and anti-inflammatory effects, promoting PI3K/Akt/CREB signaling, and thus, inhibiting p-tau formation.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
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