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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 79 - 85 (7page)
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초록· 키워드
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Polyphenolic compounds are reported to have various pharmacological activities such as anti-oxidative, anti-cancerous, anti-inflammatory and anti-aging effects. Although numerous papers explore their functional roles in many different cellular actions, not many studies handle their structural features in anti-inflammatory responses. In this study, therefore, we examined structural role of substituted transstilbenes in their NO inhibitory and NF-${\kappa}B$ suppressive activities. Of 10 compounds tested, 4 compounds (cinnamic acid, resveratrol, piceatannol and curcumin) displayed NO inhibitory activities in a dose-dependent manner. Similarly, these compounds blocked LPS-induced cytotoxicity of RAW264.7 cells. All NO inhibitory compounds also inhibited $I{\kappa}B{\alpha}$ phosphorylation, a hallmark for NF-${\kappa}B$ activation. However, these inhibitory compounds exhibited distinct suppressive pattern in tumor necrosis factor (TNF)-${\alpha}$- or phorbol-12-myristate-13-acetate (PMA)-induced NF-${\kappa}B$ and AP-1 activation. According to structure-activity relationship study, polarity and size of ring B seem to be important for diminishing NO production. Therefore, our data suggest that substituted trans-stilbenes can be developed as novel anti-inflammatory drug or further developed as lead compounds for another improvement.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Butchar, J. P. / 2006 / Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response / Curr Pharm Des 12:4143~4153
Callsen, D. / 1999 / Role of mitogen-activated protein kinases in S-nitrosoglutathione-induced macrophage apoptosis / Biochemistry 38:2279~2286
Chen, L. / 2007 / Cancer preventive mechanisms of the green tea polyphenol (-)-epigallocatechin-3- gallate / Molecules 12:946~957
Cho, J. Y. / 2004 / Differential effect of phosphodiesterase IV inhibitor RP73401 on various inflammatory and immune responses relevent to rheumatoid arthritis / Pharmacol Res 49:423~431
Doyle, S. L. / 2006 / Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity / Biochem Pharmacol 72:1102~1113
Callsen, D. / 1999 / Role of mitogen-activated protein kinases in S-nitrosoglutathione-induced macrophage apoptosis / Biochemistry 38:2279~2286
Chen, L. / 2007 / Cancer preventive mechanisms of the green tea polyphenol (-)-epigallocatechin-3- gallate / Molecules 12:946~957
Cho, J. Y. / 2004 / Differential effect of phosphodiesterase IV inhibitor RP73401 on various inflammatory and immune responses relevent to rheumatoid arthritis / Pharmacol Res 49:423~431
Doyle, S. L. / 2006 / Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity / Biochem Pharmacol 72:1102~1113
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