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논문 기본 정보

자료유형
학술저널
저자정보
Lee, Hwa-Jeong (College of Pharmacy, Chungbuk National University) Jeong, Heon-Sang (College of Agriculture, Life and Environment, Chungbuk National University) Kim, Dae-Joong (College of Veterinary Medicine, Chungbuk National University) Noh, Young-Hee (Department of Medical Beauty, konyang University) Yuk, Dong-yeon (College of Pharmacy, Chungbuk National University) Hong, Jin-Tae (College of Pharmacy, Chungbuk National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제3호
발행연도
2008.1
수록면
342 - 349 (8page)

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Citral is a major compound of lemongrass (Cymbopogon citratus L.) that has many pharmacological activities such as anti-fungal and anti-bacterial effects. In this study, we investigated the anti-inflammatory effect of citral and defined its mechanism of action in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Citral (3-12 ${\mu}g/mL$) significantly inhibited LPS-induced nitric oxide (NO) production in a concentration-dependent manner ($IC_{50}:\;6.5\;{\mu}g/mL$). Furthermore, it was found that citral effectively inhibited the transcriptional activity and expression of iNOS, and potently suppressed the DNA binding activity and nuclear translocation of $NF-{\kappa}B$ as well as $I{\kappa}B$ phosphorylation in a concentration dependent manner. These results suggest that citral is anti-inflammatory, and its effects may be due to the inhibition of NO production through the suppression of $NF-{\kappa}B$ activation.

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