지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 97 - 101 (5page)
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초록· 키워드
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Cirsium japonicum var. ussuriense is known to have a variety of biological activities, including anti-inflammatory, analgesic activity and antipyretic activity. In this study we investigated the role of polyacetylene compound, 1-Heptadecene-11, 13-diyne-8, 9, 10-triol (PA) from the root of Cirsium japonicum var. ussuriense as an immune-modulator. PA was evaluated as inhibitors of some macrophage functions involved in the inflammatory process. We tested the effect of PA on the production of pro-inflammatory cytokines, interleukin-1beta (IL-$1{\beta}$) and tumor necrosis factor-alpha (TNF-$\alpha$), and nitric oxide (NO) in murine macrophage cell line, RAW264.7. There was no effect on cytokine production of macrophages by PA itself. However, PA inhibited lipopolysaccharide (LPS)-induced IL-$1{\beta}$ and TNF-$\alpha$ production by macrophages at a dose dependent manner. PA also suppressed the NO production of macrophages by LPS. LPS-induced NF-${\kappa}B$ activity was decreased by treatment of PA. Therefore, these results suggest that PA has anti-inflammatory effect by inhibiting the NF-${\kappa}B$ activation.
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참고문헌 (18)
참고문헌 신청
Aggarwal, B. B / 1996 / Tumor necrosis factors: developments during the last decade / Eur. Cytokine. Netw 7:93~124
Cerretti, D. P / 1992 / Molecular Cloning of the interleukin-1 beta converting enzyme / Science 256:97~100
Woong CHO / 2008 / Anti-inflammatory Effects of the Methanol Extract of Polytrichum Commune via NF-κB Inactivation in RAW 264.7 Macrophage Cells / 응용약물학회지 16(4):385~393
Doyle, S. L / 2006 / Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity / Biochem. Pharmacol 72:1102~1113
Feldmann, M / 1991 / Cytokine assays: role in evaluation of the pathogenesis of autoimmunity / Immunol. Rev 119:105~123
Cerretti, D. P / 1992 / Molecular Cloning of the interleukin-1 beta converting enzyme / Science 256:97~100
Woong CHO / 2008 / Anti-inflammatory Effects of the Methanol Extract of Polytrichum Commune via NF-κB Inactivation in RAW 264.7 Macrophage Cells / 응용약물학회지 16(4):385~393
Doyle, S. L / 2006 / Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity / Biochem. Pharmacol 72:1102~1113
Feldmann, M / 1991 / Cytokine assays: role in evaluation of the pathogenesis of autoimmunity / Immunol. Rev 119:105~123
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