개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제13권 제2호
- 발행연도
- 1990.1
- 수록면
- 147 - 150 (4page)
이용수
초록· 키워드
오류제보하기
Methotrexate (MTX)-poly-L-lysine (PLL) conjugate was relatively stable in phosphate buffer of pH 7.4 and in plasma. However, liver homogenate accelerated the release of MTX from the conjugate. Pharmacokinetics and tissue distribution of MTX were compared after intramuscular injection of MTX (treatment I) and MTX-PLL conjugate (treatment II), 10 mg/kg as free MTX to rabbits. The peak concentration of MTX in treatment II were significantly lower than those in treatment I. The amount of MTX excreted in 24-hr urine was significantly reduced in treatment II and it suggested that MTX be more metabolized in treatment II than in treatment I. The amounts of MTX remaining in each organ after 24-hr of intramuscular injection were not significantly different in both treatments.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Serum methotrexate level is inversely related to the outcome of osteosarcoma patients
Clinical and Experimental Pediatrics
2009 .01
-
$[^3H]$-메토트렉세이트-락토오스아미노화한 소 혈청 알부민 공유결합체의 간표적성 및 체내동태
약학회지
1992 .01
-
Ultrasound-guided local injection of methotrexate and systemic intramuscular methotrexate in the treatment of cesarean scar pregnancy
Obstetrics & Gynecology Science
2018 .01
-
소아 급성림프모구백혈병 및 비호지킨림프종 환자에서 고용량 methotrexate 투여 후 배설지연
한국임상약학회지
2019 .01
-
골육종 세포주에서 메토트렉세이트-LDH 혼성체의 증식 억제 효과
대한정형외과학회지
2004 .02
-
In vitro Drug Release Characteristics of Methotrexate-Human Serum Albumin and 5-Fluorouracil-Acetic Acid Human Serum Albumin Conjugates
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1989 .01
-
신기능이 저하된 환자에서 저용량 메토트렉세이트에 의한 범혈구감소증
대한내과학회지
2009 .01
-
Gene Expression Analysis of Methotrexate-induced Hepatotoxicity between in vitro and in vivo
Molecular & cellular toxicology
2005 .01
-
Pharmacokinetics of High-dose Methotrexate in Pediatric Patients with Osteosarcoma
한국임상약학회지
2006 .01
-
Intralesional Methotrexate for the Treatment of Keratoacanthoma: Retrospective Study and Review of the Korean Literature
Annals of Dermatology
2014 .01
-
Evaluation of risk for graft-versus-host disease in children who receive less than the full doses of mini-dose methotrexate for graft-versus-host disease prophylaxis in allogeneic hematopoietic stem cell transplantation
Clinical and Experimental Pediatrics
2013 .01
-
Methotrexate-induced Oral Mucositis
Journal of Oral Medicine and Pain
2015 .06
-
자궁경관 임신에서 자궁경관 흡입 소파술 및 국소 Methotrexate 주입술과 병합한 전신 Methotrexate의 단회요법과 다회요법의 비교
Obstetrics & Gynecology Science
2008 .01
-
Low-dose Methotrexate Therapy for Intravenous Immunoglobulin-resistant Kawasaki Disease
Yonsei Medical Journal
2008 .01
-
류마티스 관절염을 가진 만성신질환 환자에서 저용량 methotrexate 투여 후 발생한 중증 범혈구 감소증 2예
영남의대학술지
2011 .01
-
Clinical Outcomes of Low-Dose Methotrexate Therapy as a Second-Line Drug for Intravenous Immunoglobulin-Resistant Kawasaki Disease
Yonsei Medical Journal
2018 .01
-
B형 간염 건강 보균자인 노인에서 장기간 저용량 Methotrexate (MTX) 투약으로 발생한 간 경변증 1예
Korean Journal of Family Medicine
2006 .01
-
A Case of Cutaneous Side Effect of Methotrexate Mimicking Behçet’s Disease
Annals of Dermatology
2011 .01
-
Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management
Cancer Research and Treatment
2011 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0