지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 67 - 70 (4page)
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초록· 키워드
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High-dose methotrexate (MTX) chemotherapy extends the duration of hospitalization and introduces the risks of serious complications related to delayed MTX excretion. The treatment of delayed MTX excretion is largely dependent on invasive measures such as hemodialysis because the clinical data regarding the efficacy or safety of carboxypetidase G2 is limited. We report here on the cases of two pediatric osteosarcoma patients with delayed MTX excretion and who were successfully managed using supportive measures.
Potential life-threatening complications were prevented by administering high doses of leucovorin.
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참고문헌 (15)
참고문헌 신청
Abelson HT / 1983 / Methotrexate- induced renal impairment: clinical studies and rescue from systemic toxicity with high-dose leucovorin and thymidine / J Clin Oncol 1 : 208
Biswal BK / 2009 / Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells / J Biochem 146 : 693 ~ 703
Bleyer WA / 1978 / The clinical pharmacology of methotrexate: new applications of an old drug / Cancer 41 : 36 ~ 51
Cassano WF / 1989 / Serious methotrexate toxicity caused by interaction with ibuprofen / Am J Pediatr Hematol Oncol 11 : 481 ~ 482
Delepine N / 1995 / Dose escalation with pharmacokinetics monitoring in methotrexate chemotherapy of osteosarcoma / Anticancer Res 15 : 489 ~ 494
Biswal BK / 2009 / Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells / J Biochem 146 : 693 ~ 703
Bleyer WA / 1978 / The clinical pharmacology of methotrexate: new applications of an old drug / Cancer 41 : 36 ~ 51
Cassano WF / 1989 / Serious methotrexate toxicity caused by interaction with ibuprofen / Am J Pediatr Hematol Oncol 11 : 481 ~ 482
Delepine N / 1995 / Dose escalation with pharmacokinetics monitoring in methotrexate chemotherapy of osteosarcoma / Anticancer Res 15 : 489 ~ 494
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