지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 82 - 87 (6page)
이용수
초록· 키워드
오류제보하기
Methotrexate (MTX) is a chemotherapeutic agent that is used to treat a host of malignancies. But recently, MTX has also been used as a therapeutic agent for chronic inflammatory disorders such as rheumatoid arthritis, psoriasis, and systemic lupus erythematosus. However, MTX is an antimetabolite that affects rapidly dividing normal cells such as oral mucosal epithelial cells, gastrointestinal epithelial cells, and bone marrow cells?which explains why oral mucositis is often an initial manifestation of MTX toxicity. Because oral lesions are frequently initially presented in dental clinics, dentists should consider the possibility of adverse drug reactions in the differential diagnoses of oral lesions through a meticulous collection of patients’ medical histories. In this report, we examine patients who suffered from oral ulcerative lesions upon diagnosis of MTX-induced oral mucositis. Then, we suggest approaches for the diagnosis and treatment of MTX-induced oral mucositis through a review of literature.
목차
INTRODUCTION
CASES REPORT
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Kremer JM / 2004 / Toward a better understanding of methotrexate / Arthritis Rheum 50 : 1370 ~ 1382
[학술지(정기간행물)] - Cipriani P / 2014 / Methotrexate:an old new drug in autoimmune disease / Expert Rev Clin Immunol 10 : 1519 ~ 1530
[학술지(정기간행물)] - Czarnecka-Operacz M / 2014 / The possibilities and principles of methotrexate treatment of psoriasis: the updated knowledge / Postepy Dermatol Alergol 31 : 392 ~ 400
[학술지(정기간행물)] - Sakthiswary R / 2014 / Methotrexate in systemic lupus erythematosus:a systematic review of its efficacy / Lupus 23 : 225 ~ 235
[학술지(정기간행물)] - Bremer JP / 2010 / Methotrexate plus leflunomide for the treatment of relapsing Wegener’s granulomatosis. A retrospective uncontrolled study / Clin Exp Rheumatol 28 (1 Suppl 57) : 67 ~ 71
[학술지(정기간행물)] - Cipriani P / 2014 / Methotrexate:an old new drug in autoimmune disease / Expert Rev Clin Immunol 10 : 1519 ~ 1530
[학술지(정기간행물)] - Czarnecka-Operacz M / 2014 / The possibilities and principles of methotrexate treatment of psoriasis: the updated knowledge / Postepy Dermatol Alergol 31 : 392 ~ 400
[학술지(정기간행물)] - Sakthiswary R / 2014 / Methotrexate in systemic lupus erythematosus:a systematic review of its efficacy / Lupus 23 : 225 ~ 235
[학술지(정기간행물)] - Bremer JP / 2010 / Methotrexate plus leflunomide for the treatment of relapsing Wegener’s granulomatosis. A retrospective uncontrolled study / Clin Exp Rheumatol 28 (1 Suppl 57) : 67 ~ 71
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UCI(KEPA) : I410-ECN-0101-2016-515-001683626