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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 50 - 65 (16page)
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Ceramides are minor components of the hepatic lipidome that have major effects on liver function. These products of lipid and protein metabolism accumulate when the energy needs of the hepatocyte have been met and its storage capacity is full, such that free fatty acids start to couple to the sphingoid backbone rather than the glycerol moiety that is the scaffold for glycerolipids (e.g., triglycerides) or the carnitine moiety that shunts them into mitochondria. As ceramides accrue, they initiate actions that protect cells from acute increases in detergent-like fatty acids; for example, they alter cellular substrate preference from glucose to lipids and they enhance triglyceride storage. When prolonged, these ceramide actions cause insulin resistance and hepatic steatosis, 2 of the underlying drivers of cardiometabolic diseases. Herein the author discusses the mechanisms linking ceramides to the development of insulin resistance, hepatosteatosis and resultant cardiometabolic disorders.
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참고문헌 (91)
참고문헌 신청
Cahill GF Jr / 1976 / Starvation in man / Clin Endocrinol Metab 5:397~415
Chaurasia B / 2019 / Targeting a ceramide double bond improves insulin resistance and hepatic steatosis / Science 365:386~392
Merrill AH Jr / 2002 / De novo sphingolipid biosynthesis : a necessary, but dangerous, pathway / J Biol Chem 277:25843~25846
Lone MA / 2019 / 1-Deoxysphingolipids / Biochim Biophys Acta Mol Cell Biol Lipids 1864:512~521
Davis D / 2018 / Orm/ORMDL proteins : gate guardians and master regulators / Adv Biol Regul 70:3~18
Chaurasia B / 2019 / Targeting a ceramide double bond improves insulin resistance and hepatic steatosis / Science 365:386~392
Merrill AH Jr / 2002 / De novo sphingolipid biosynthesis : a necessary, but dangerous, pathway / J Biol Chem 277:25843~25846
Lone MA / 2019 / 1-Deoxysphingolipids / Biochim Biophys Acta Mol Cell Biol Lipids 1864:512~521
Davis D / 2018 / Orm/ORMDL proteins : gate guardians and master regulators / Adv Biol Regul 70:3~18
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