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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 268 - 281 (14page)
- DOI
- 10.12997/jla.2021.10.3.268
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초록· 키워드
오류제보하기
Sphingolipids (SLs) are critical players in a number of cellular processes and have recently been implicated in a large number of human diseases, including atherosclerosis and cardiovascular disease (CVD). SLs are generated intracellularly in a stepwise manner, starting with the generation of the sphingoid long chain base (LCB), followed by N-acylation of the LCB to form ceramide, which can be subsequently metabolized to sphingomyelin and glycosphingolipids. Fatty acids, which are taken up by cells prior to their activation to fatty acyl-CoAs, are used in 2 of these enzymatic steps, including by ceramide synthases, which use fatty acyl-CoAs of different chain lengths to generate ceramides with different N-acyl chain lengths. Recently, alterations in plasma ceramides with specific N-acyl chain lengths and degrees of saturation have emerged as novel biomarkers for the prediction of atherosclerosis and overall cardiovascular risk in the general population. We briefly review the sources of plasma SLs in atherosclerosis, the roles of SLs in CVD, and the possible use of the “ceramide score” as a prognostic marker for CVD.
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참고문헌 (115)
참고문헌 신청
Saddoughi SA / 2013 / Diverse functions of ceramide in cancer cell death and proliferation / Adv Cancer Res 117:37~58
Jensen SA / 2014 / Bcl2L13 is a ceramide synthase inhibitor in glioblastoma / Proc Natl Acad Sci U S A 111:5682~5687
Mosbech MB / 2014 / Reduced ceramide synthase 2activity causes progressive myoclonic epilepsy / Ann Clin Transl Neurol 1:88~98
Garić D / 2019 / Biochemistry of very-long-chain and longchain ceramides in cystic fibrosis and other diseases : the importance of side chain / Prog Lipid Res 74:130~144
Summers SA / 2019 / Metabolic messengers : ceramides / Nat Metab 1:1051~1058
Jensen SA / 2014 / Bcl2L13 is a ceramide synthase inhibitor in glioblastoma / Proc Natl Acad Sci U S A 111:5682~5687
Mosbech MB / 2014 / Reduced ceramide synthase 2activity causes progressive myoclonic epilepsy / Ann Clin Transl Neurol 1:88~98
Garić D / 2019 / Biochemistry of very-long-chain and longchain ceramides in cystic fibrosis and other diseases : the importance of side chain / Prog Lipid Res 74:130~144
Summers SA / 2019 / Metabolic messengers : ceramides / Nat Metab 1:1051~1058
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