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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 164 - 174 (11page)
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Background: The ceramide is known to play an important role in the formation of intracellular lipids, and play a crucial role as a barrier for skin and hair cuticle. Recent study has revealed that ceramide has potential effect on hair growth in a mouse model. However, the role of ceramide in human dermal papilla cells (hDPCs) known to play an important role in hair growth is not well understood yet. Objective: The goal of this study was to investigate the effect of synthetic ceramides (oleyl and stearyl ceramides) on hair growth using hDPCs. Methods: hDPCs were treated with synthesized ceramides. hDPCs viability was evaluated by MTT assay. The expression of hair growth related factors were investigated by western blot, real-time polymerase chain reaction and growth factor array. The expression of β-catenin was confirmed by immunofluorescence. Results: Treatment with ceramides increased the expression of proteins affecting cell proliferation such as Bcl-2, BAX, phosphorylated-ERK and Cyclin D1. Also, ceramides treatment were increased the expression of several growth factors, including epidermal growth factor family, and promote the expression of Wnt/ β-catenin and BMP2/4 signaling. Conclusion: Our data suggest that synthetic ceramides stimulates hair growth by induction proliferation of hDPCs via modulation of Wnt/β -catenin and BMP2/4 signaling.
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참고문헌 (35)
참고문헌 신청
Trüeb RM / 2009 / Oxidative stress in ageing of hair / Int J Trichology 1:6~14
Andl T / 2002 / WNT signals are required for the initiation of hair follicle development / Dev Cell 2:643~653
Takahashi T / 2015 / Age-dependent changes in damage processes of hair cuticle / J Cosmet Dermatol 14:2~8
Lee WS / 2005 / Integral lipid in human hair follicle / J Investig Dermatol Symp Proc 10:234~237
Sasaki T / 1995 / Permissive effect of ceramide on growth factor-induced cell proliferation / Biochem J 311:829~834
Andl T / 2002 / WNT signals are required for the initiation of hair follicle development / Dev Cell 2:643~653
Takahashi T / 2015 / Age-dependent changes in damage processes of hair cuticle / J Cosmet Dermatol 14:2~8
Lee WS / 2005 / Integral lipid in human hair follicle / J Investig Dermatol Symp Proc 10:234~237
Sasaki T / 1995 / Permissive effect of ceramide on growth factor-induced cell proliferation / Biochem J 311:829~834
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