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논문 기본 정보
- 자료유형
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- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제3호
- 발행연도
- 2020.1
- 수록면
- 295 - 307 (13page)
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Background The bioactive sphingolipids such as ceramide, sphingosine, and sphingosine-1-phosphate are of special interest as key regulators of cellular proliferation or apoptosis signaling. The balance between ceramide and sphingosine-1-phosphate is critical for the selection of proliferative or apoptotic signaling as well as for therapeutic efficacy against cancer cells. Area covered A number of drug candidates designed to regulate the balance between ceramide and sphingosine-1-phosphate have been developed and several (i.e., safingol, ABC294640, Sonepcizumab, and fingolimod) are under clinical investigation as anti-cancer drugs. Various nanotherapeutic challenges combined with the use of anticancer drugs and/or phospholipid metabolism inhibitors and short chain ceramide has been investigated to increase the cellular accumulation of ceramide, which acts as apoptotic signaling molecules. Expert opinion Many sphingolipid-containing nanotherapeutics have shown promising results as cancer treatments. These sphingolipid nanotherapeutics can include a synergistic combination of short chain ceramide and ceramide-forming anticancer agents or sphingolipid metabolism inhibitors. Sphingolipid nanotherapeutics could also be used to treat multidrug-resistant cancer cells as well as sensitive cancer cells.
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참고문헌 (86)
참고문헌 신청
Allen TM / 2013 / Liposomal drug delivery systems : from concept to clinical applications / Adv Drug Deliv Rev 65(1):36~48
Allen TM / 1989 / Liposomes with prolonged circulation times : factors affecting uptake by reticuloendothelial and other tissues / Biochim Biophys Acta 981(1):27~35
Baran Y / 2011 / Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation / J Cancer Res Clin Oncol 137(10):1535~1544
Barth BM / 2011 / Ceramide-based therapeutics for the treatment of cancer / Anticancer Agents Med Chem 11(9):911~919
Barth BM / 2010 / Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance / Cancer Biol Ther 10(11):1126~1137
Allen TM / 1989 / Liposomes with prolonged circulation times : factors affecting uptake by reticuloendothelial and other tissues / Biochim Biophys Acta 981(1):27~35
Baran Y / 2011 / Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation / J Cancer Res Clin Oncol 137(10):1535~1544
Barth BM / 2011 / Ceramide-based therapeutics for the treatment of cancer / Anticancer Agents Med Chem 11(9):911~919
Barth BM / 2010 / Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance / Cancer Biol Ther 10(11):1126~1137
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