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논문 기본 정보

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학술저널
저자정보
Kim, Minjeong (Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University) Jeong, Haengdueng (Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine) Lee, Buhyun (Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine) Cho, Yejin (Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine) Yoon, Won Kee (Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology [KRIBB]) Cho, Ahreum (Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University) Kwon, Guideock (Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University) Nam, Ki Taek (Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine) Ha, Hunjoo (Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University) Lim, Kyung-Min (Graduate School of Pha)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제27권 제5호
발행연도
2019.1
수록면
457 - 465 (9page)

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Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in DM skin disorders, we quantitated 49 lipids (34 ceramides, 14 free fatty acids (FFAs), and cholesterol) in the skin epidermis, liver, and kidneys of db/db mice, a Type 2 DM model, using UPLC-MS/MS. The expression of genes involved in lipid synthesis was also evaluated. With the full establishment of hyperglycemia at the age of 20 weeks, remarkable lipid enrichment was noted in the skin of the db/db mice, especially at the epidermis and subcutaneous fat bed. Prominent increases in the ceramides and FFAs (>3 fold) with short or medium chains (<C26) occurred in the skin epidermis (16NS, 18NS, 24NS, 16NDS, 18NDS, 20NDS, 22NDS, 24NDS, C16:1FA, C18:2FA, and C18:1FA) and the liver (16NS, 18NS, 20NS, 24:1NS, 18NDS, 20NDS, 22NDS, C16:1FA, C18:2FA, C18:1FA), whereas those with very long chains were not affected. In the kidney, only slight increases (<3 fold) were observed for 16NS, 18NS, 20NS, 26NDS, C26FA, and C22:1FA. Consistently, $LXR{\alpha}/{\beta}$ and $PPAR{\gamma}$, nuclear receptors promoting lipid synthesis, lipid synthesis enzymes such as elongases 1, 4, and 6, and fatty acid synthase and stearoyl-CoA desaturase were highly expressed in the skin and livers of the db/db mice. Collectively, our study demonstrates an extensive alteration in the skin and systemic lipid profiles of db/db mice, which could contribute to the development of skin disorders in DM.
#Lipids #Ceramide #Free fatty acid #Diabetes mellitus #Skin barrier function

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참고문헌 (49)

참고문헌 신청
Breiden, B / 2014 / The role of sphingolipid metabolism in cutaneous permeability barrier formation / Biochim. Biophys. Acta 1841:441~452 google schola Czarnowicki, T / 2018 / Effect of short-term liver X receptor activation on epidermal barrier features in mild to moderate atopic dermatitis : A randomized controlled trial / Ann. Allergy. Asthma. Immunol 120:631~640 google schola Danso, M. O / 2017 / Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition / J. Dermatol. Sci 88:57~66 google schola Demirseren, D. D / 2014 / Relationship between skin diseases and extracutaneous complications of diabetes mellitus : clinical analysis of 750 patients / Am. J. Clin. Dermatol 15:65~70 google schola Elias, P. M / 2005 / Stratum corneum defensive functions : an integrated view / J. Invest. Dermatol 125:183~200 google schola

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