지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 640 - 650 (11page)
이용수
초록· 키워드
오류제보하기
Purpose: Alzheimer’s disease (AD) is the most common neurodegenerative disease, with a rising prevalence worldwide. Longnoncoding RNAs (lncRNAs) have been found to play important roles in the development and treatment of AD. However, the exactrole of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in neuronal damage in AD is largely unknown. Materials and Methods: The AD model was established in SH-SY5Y and SK-N-SH cells via treatment with amyloid β1-42 (Aβ). Theexpression of NEAT1 and microRNA-107 (miR-107) was measured by quantitative real-time polymerase chain reaction. Cell viabilityand apoptosis were detected by MTT assay, immunocytochemistry, and flow cytometry. The expression of phosphorylated tauprotein (p-Tau) was measured by Western blot. The interaction between NEAT1 and miR-107 was explored by bioinformaticsanalysis, luciferase activity, and RNA immunoprecipitation assays. Results: NEAT1 expression was enhanced in Aβ-treated SH-SY5Y and SK-N-SH cells, and its knockdown attenuated Aβ-inducedinhibition of viability and promotion of apoptosis and p-Tau levels. NEAT1 was indicated as a decoy of miR-107. miR-107 abundancewas reduced in Aβ-treated cells, and its overexpression reversed Aβ-induced injury. Moreover, interference of miR-107 abatedsilencing of NEAT1-mediated inhibition of neuronal damage in Aβ-treated SH-SY5Y and SK-N-SH cells. Conclusion: LncRNA NEAT1 aggravated Aβ-induced neuronal damage by sponging miR-107, indicating a novel avenue for treatmentof AD.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Scheltens P / 2016 / Alzheimer’s disease / Lancet 388:505~517
Chen Y / 2019 / Synaptic dysfunction in Alzheimer’s disease : mechanisms and therapeutic strategies / Pharmacol Ther 195:186~198
Nasica-Labouze J / 2015 / Amyloid β protein and Alzheimer’s disease : when computer simulations complement experimental studies / Chem Rev 115:3518~3563
Li C / 2017 / Tau-based therapies in neurodegeneration : opportunities and challenges / Nat Rev Drug Discov 16:863~883
Idda ML / 2018 / Noncoding RNAs in Alzheimer’s disease / Wiley Interdiscip Rev RNA 9:e1463
Chen Y / 2019 / Synaptic dysfunction in Alzheimer’s disease : mechanisms and therapeutic strategies / Pharmacol Ther 195:186~198
Nasica-Labouze J / 2015 / Amyloid β protein and Alzheimer’s disease : when computer simulations complement experimental studies / Chem Rev 115:3518~3563
Li C / 2017 / Tau-based therapies in neurodegeneration : opportunities and challenges / Nat Rev Drug Discov 16:863~883
Idda ML / 2018 / Noncoding RNAs in Alzheimer’s disease / Wiley Interdiscip Rev RNA 9:e1463
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Long Noncoding RNA NEAT1 Targets miR-34a-5p and Drives Nasopharyngeal Carcinoma Progression via Wnt/β-Catenin Signaling
Yonsei Medical Journal
2019 .01
-
Knockdown of Long Non-Coding RNA NEAT1 Inhibits Proliferation and Invasion and Induces Apoptosis of Osteosarcoma by Inhibiting miR-194 Expression
Yonsei Medical Journal
2017 .01
-
MiR-212 Attenuates MPP+-Induced Neuronal Damage by Targeting KLF4 in SH-SY5Y Cells
Yonsei Medical Journal
2018 .01
-
Upregulation and Clinicopathological Significance of Long Non-coding NEAT1 RNA in NSCLC Tissues
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Knockdown of LncRNA H19 Relieves LPS-Induced Damage by Modulating miR-130a in Osteoarthritis
Yonsei Medical Journal
2019 .01
-
Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients
Clinical Psychopharmacology and Neuroscience
2016 .01
-
Down Regulation of miR-34a and miR-143 May Indirectly Inhibit p53 in Oral Squamous Cell Carcinoma: a Pilot Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
miR-196b-5p and miR-375 Expression in Gastric Cancer
대한임상종양학회 학술대회지
2016 .02
-
Upregulation of miR-27b Facilitates Apoptosis of TNF-α-Stimulated Fibroblast-Like Synoviocytes
Yonsei Medical Journal
2019 .01
-
Circulating Plasma Micro RNAs in Patients with Major Depressive Disorder Treated with Antidepressants: A Pilot Study
PSYCHIATRY INVESTIGATION
2016 .01
-
MiR-675 Promotes the Growth of Hepatocellular Carcinoma Cells Through Cdc25A Pathway
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Regulation of Colonic Mucosal MicroRNA Expression via Multiple Targets in Visceral Hypersensitivity Rats by Tongxieyaofang
Yonsei Medical Journal
2018 .01
-
MiR-182-5p Knockdown Targeting PTEN Inhibits Cell Proliferation and Invasion of Breast Cancer Cells
Yonsei Medical Journal
2019 .01
-
AC092127.1-miR-451a-AE binding protein 2 Signaling Facilitates Malignant Properties of Breast Cancer
Journal of Breast Cancer
2021 .08
-
MicroRNA Expression in Plasma of Esophageal Squamous Cell Carcinoma Patients
Journal of Korean Medical Science
2022 .06
-
A novel panel of serum miR-21/miR-155/miR-365 as a potential diagnostic biomarker for breast cancer
Annals of Surgical Treatment and Research
2017 .02
-
miR-195/miR-497 Regulate CD274 Expression of Immune Regulatory Ligands in Triple-Negative Breast Cancer
Journal of Breast Cancer
2018 .01
-
Expression of miR-221 and miR-18a in patients with hepatocellular carcinoma and its clinical significance
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2022 .06
-
Combined Detection of Serum MiR-221-3p and MiR-122-5p Expression in Diagnosis and Prognosis of Gastric Cancer
Journal of Gastric Cancer
2019 .01
-
Long non-coding RNA T-cell leukemia/lymphoma 6 serves as a sponge for miR-21 modulating the cell proliferation of retinoblastoma through PTEN
The Korean Journal of Physiology & Pharmacology
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0