지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 321 - 325 (5page)
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초록· 키워드
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This study investigated resistance mechanisms and epidemiology of emerging linezolid-nonsusceptible Enterococcus faecalis (LNSEF) in a tertiary care hospital. LNSEF isolated from clinical samples were collected from November 2017 to June 2019. The isolates were investigated for linezolid resistance and the associated molecular mechanisms, including mutations of 23S rRNA domain V and acquisition of the cfr or optrA resistance gene. We used pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing for the molecular typing of the isolates. Among 4,318 E. faecalis isolates, 10 (0.23%) were linezolid-nonsusceptible. All LNSEF isolates were optrA-positive and cfr-negative. Of these isolates, five were sequence type (ST) 476, two ST585, one ST16, one ST16-like, and one ST480. Six LNSEF isolates obtained in the first year clustered to three types in the PFGE analysis: two ST476 isolates of type A, two ST585 isolates of type B, and two ST16 or ST16-like isolates of type C. Seven cases were of community-onset and three were hospital acquired, but total of eight were healthcare-associated including five community-onset. None of the patients had a history of linezolid treatment, and in one patient, we detected linezolid-susceptible E. faecalis one month before LNSEF detection. In conclusion, heterogenous clones of optrA-positive LNSEF emerged in the hospital mainly via community-onset.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Mendes RE / 2014 / Linezolid update: stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanisms / Drug Resist Updat 17:1~12
Bae HG / 2006 / First report of a linezolid- and vancomycin-resistant Enterococcus faecium strain in Korea / Scand J Infect Dis 38:383~386
Lee SM / 2017 / Resistance mechanisms of linezolid-nonsusceptible enterococci in Korea: low rate of 23S rRNA mutations in Enterococcus faecium / J Med Microbiol 66:1730~1735
Cui L / 2016 / Nationwide surveillance of novel oxazolidinone resistance gene optrA in Enterococcus isolates in China from 2004 to 2014 / Antimicrob Agents Chemother 60:7490~7493
Deshpande LM / 2018 / Evolving oxazolidinone resistance mechanisms in a worldwide collection of enterococcal clinical isolates: results from the SENTRY Antimicrobial Surveillance Program / J Antimicrob Chemother 73:2314~2322
Bae HG / 2006 / First report of a linezolid- and vancomycin-resistant Enterococcus faecium strain in Korea / Scand J Infect Dis 38:383~386
Lee SM / 2017 / Resistance mechanisms of linezolid-nonsusceptible enterococci in Korea: low rate of 23S rRNA mutations in Enterococcus faecium / J Med Microbiol 66:1730~1735
Cui L / 2016 / Nationwide surveillance of novel oxazolidinone resistance gene optrA in Enterococcus isolates in China from 2004 to 2014 / Antimicrob Agents Chemother 60:7490~7493
Deshpande LM / 2018 / Evolving oxazolidinone resistance mechanisms in a worldwide collection of enterococcal clinical isolates: results from the SENTRY Antimicrobial Surveillance Program / J Antimicrob Chemother 73:2314~2322
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