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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 99 - 106 (8page)
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Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is considered to be the primary cause of hospital acquired pneumonia (HAP) and MRSA-associated HAP occur a significant impact on healthcare resource use and associated economic costs. The objective of this study was to investigate the economic impact of linezolid compared with that of vancomycin in the treatment of hospitalized pa- tients with MRSA-confirmed HAP in the Korea. Methods: A 30-days decision tree model incorporat- ed published data on clinical parameters, resource use, and costs were constructed. The base case first- line treatment duration for patients with hospital-acquired pneumonia was 10 days. Treatment success, discontinuation due to adverse events, discontinuation due to lack of efficacy, and mortality were possi- ble outcomes that could impact costs. Results: The model calculated that linezolid was associated with an 1.8% higher cure rate compared with vancomycin (62.5% vs. 60.7%, respectively). Average total costs per episode for linezolid-and vancomycin-treated patients were KRW 3420971 and 3459977 respective- ly. The incremental cost-effectiveness ratio favored linezolid (versus vancomycin), with marginally low- er costs (by KRW 39006) and greater efficacy (+1.8% absolute difference in the proportion of patients successfully treated for MRSA HAP). Conclusion: The study shows that linezolid is a cost-effective al- ternative to vancomycin for HAP.
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참고문헌 (20)
참고문헌 신청
Jawetz E / 1991 / Medical microbiology / Appleton Lange
Jevons MP / 1961 / Celbenin-resistant Staphylococci / Br Med J 1:124~125
Woo HY / 2000 / Molecular epidemiological study and analysis of genomic diversity of mec regulator genes in mecA positive methicillin-resistant staphylococci / J Korean Soc Chemother 18:335~354
Jin HY / 1999 / Effective control of MRSA nosocomial infection in intensive care unit / Korean J Noscomial Infect control 4:7~16
Kollef MH / 2005 / Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia / Chest 128:3854~3862
Jevons MP / 1961 / Celbenin-resistant Staphylococci / Br Med J 1:124~125
Woo HY / 2000 / Molecular epidemiological study and analysis of genomic diversity of mec regulator genes in mecA positive methicillin-resistant staphylococci / J Korean Soc Chemother 18:335~354
Jin HY / 1999 / Effective control of MRSA nosocomial infection in intensive care unit / Korean J Noscomial Infect control 4:7~16
Kollef MH / 2005 / Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia / Chest 128:3854~3862
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