지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 107 - 118 (12page)
이용수
초록· 키워드
오류제보하기
Background Pseudomonas aeruginosa is considered as one of the most emerging threats in this century. Serious infections caused by this pathogen are often treated by carbapenems which are the last resource of antibiotics. Metallo-beta-lactamases (MBLs) production is one of the most important carbepenem resistance mechanisms and is usually related with nosocomial infections caused by P. aeruginosa. This study was aimed to determine the prevalence of MBL genes and distribution pattern of MBLs producing P. aeruginosa strains in Thailand. Materials and Methods Specific primers were designed to detect MBL genes including IMP-, VIM-, and NDM-type MBL genes. Multilocus sequence typing method was used to determine the dissemination pattern of carbapenem-resistance among multidrug-resistant (CR-MDR) P. aeruginosa. Results A total of 153 P. aeruginosa clinical isolates were characterized as CR-MDR. Among those, 31 P. aeruginosa clinical isolates (20.3%) presented metallo-beta-lactamase genes which could be divided into VIM-type (14 strains) and IMP-type (17 strains). blaIMP-1,blaIMP-13,blaIMP-14a, and blaVIM-2 genes were detected. Moreover, a novel IMP-type MBL, blaIMP-65 was discovered and it was demonstrated to be the unique group of MBLs in Thailand. It was of interest that ST235 was the major ST type in Thailand followed by ST964 and ST111 and ST235 was detected in both MBL harboring and non-MBL harboring strains. Conclusion This study reported the dissemination of MBL gene including novel MBL, blaIMP-65. This study was also demonstrated major ST of P. aeruginosa which was ST235, followed by ST964 and ST111. Moreover, it is also the first report on many P. aeruginosa STs in Thailand: ST273, ST292, ST621, ST1584, and ST1816 which emphasized the dissemination trait difference of MBLs harboring P. aeruginosa in Thailand.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Boucher HW / 2009 / Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America / Clin Infect Dis 48:1~12
World Health Organization (WHO) / WHO publishes list of bacteria for which new antibiotics are urgently needed
Santajit S / 2016 / Mechanisms of antimicrobial resistance in ESKAPE pathogens / Biomed Res Int 2016:2475067
Pérez-Losada M / 2013 / Pathogen typing in the genomics era : MLST and the future of molecular epidemiology / Infect Genet Evol 16:38~53
Curran B / 2004 / Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa / J Clin Microbiol 42:5644~5649
World Health Organization (WHO) / WHO publishes list of bacteria for which new antibiotics are urgently needed
Santajit S / 2016 / Mechanisms of antimicrobial resistance in ESKAPE pathogens / Biomed Res Int 2016:2475067
Pérez-Losada M / 2013 / Pathogen typing in the genomics era : MLST and the future of molecular epidemiology / Infect Genet Evol 16:38~53
Curran B / 2004 / Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa / J Clin Microbiol 42:5644~5649
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Molecular Epidemiology of Ciprofloxacin-Resistant Escherichia coli Isolated from Community-Acquired Urinary Tract Infections in Korea
Infection and Chemotherapy
2020 .01
-
Rapid Detection of Pseudomonas aeruginosa and Acinetobacter baumannii Harboring blaVIM-2, blaIMP-1 and blaOXA-23 Genes by Using Loop-Mediated Isothermal Amplification Methods
Annals of Laboratory Medicine
2016 .01
-
Characteristics of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Korea
Infection and Chemotherapy
2015 .01
-
Emergence of Acinetobacter pittii Harboring New Delhi Metallo-β-Lactamase Genes in Daejeon, Korea
Annals of Laboratory Medicine
2015 .01
-
ST2-high subpopulation leads to growth and metastasis of gastric cancer
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Effects of Psychotropic Drugs on Seizure Threshold during Electroconvulsive Therapy
PSYCHIATRY INVESTIGATION
2017 .01
-
Virulence Factors Associated With Escherichia coli Bacteremia and Urinary Tract Infection
Annals of Laboratory Medicine
2022 .03
-
Biological safety of acupuncture (STS316) by electrical stimulation
한국실험동물학회 학술발표대회 논문집
2017 .02
-
ST segment
International Journal of Arrhythmia
2017 .06
-
최근임상에서 분리된 다제 내성 Enterobacter cloacae의 생물학적 유전학적 특성
Laboratory Medicine Online
2018 .01
-
A Novel Integron Gene Cassette Harboring VIM-38 Metallo-β-lactamase in a Clinical Pseudomonas aeruginosa Isolate
Annals of Laboratory Medicine
2016 .01
-
Prevalence of Escherichia coli Carrying pks Islands in Bacteremia Patients
Annals of Laboratory Medicine
2018 .01
-
Molecular Epidemiology of Bacillus cereus in a Pediatric Cancer Center
Pediatric Infection and Vaccine
2016 .01
-
Increasing Carbapenem-Resistant Gram-Negative Bacilli and Decreasing Metallo-β-Lactamase Producers over Eight Years from Korea
Yonsei Medical Journal
2015 .01
-
Emergence of NDM-1–producing Pseudomonas aeruginosa Sequence Type 773 Clone: Shift of Carbapenemase Molecular Epidemiology and Spread of 16S rRNA Methylase Genes in Korea
Annals of Laboratory Medicine
2023 .03
-
Clonal and Virulence Distribution of Uropathogenic Escherichia coli Isolated from Children in Korea
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2017 .03
-
Association of Changes in Sitting Time with the Risk of Developing Diabetes: A Community-Based Cohort Study
대한스포츠의학회지
2024 .03
-
Association Among Self-Injury, Suicidal Tendency, and Personality and Psychological Characteristics in Korean Adolescents
PSYCHIATRY INVESTIGATION
2022 .01
-
Correction to “Association of Changes in Sitting Time with the Risk of Developing Diabetes: A Community-Based Cohort Study”
대한스포츠의학회지
2024 .09
-
Rapid Identification of blaIMP-1 and blaIMP-6 by Multiplex Amplification Refractory Mutation System PCR
Annals of Laboratory Medicine
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0