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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 209 - 209 (1page)
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Tumors are composed of heterogeneous cells, and only a rare subpopulation is responsible for sustaining tumorigenesis, distant metastasis, and chemoresistance. Suppression of tumorigenicity 2 (ST2), an Interleukin 33 (IL-33) receptor, is mainly expressed in immune cells. The role of the IL-33/ST2 axis has been primarily studied in inflammatory diseases. In Cdh1F/+;Trp53F/F;Smad4F/F mouse gastric cancer (GC) cells, ST2 was shown to be enriched in a cancer stem cell-like subpopulation that drives chemoresistance and tumorigenesis. Here, a ST2-positive subpopulation was found to reside in GC cells, and human GCs with high ST2 expression were associated with nodal metastasis. It was revealed that Il1rl1, which encodes ST2, is a target gene of Wnt signaling, and its expression is associated with survival against cytotoxic conditions, including chemotherapy and anoikis. Con ... 전체 초록 보기
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